Basic Information

Symbol
circHECW2
RNA Class
circRNA
Alias
HECT, C2 And WW Domain Containing E3 Ubiquitin Protein Ligase 2 NEDL2 KIAA1301 HECT-Type E3 Ubiquitin Transferase HECW2 NEDD4-Like E3 Ubiquitin-Protein Ligase 2 E3 Ubiquitin-Protein Ligase HECW2 HECT, C2 And WW Domain-Containing Protein 2 NEDD4-Related E3 Ubiquitin Ligase NEDL2 EC 2.3.2.26 EC 6.3.2 NDHSAL
Location (GRCh37)
2:197065695-197457335 UCSC Genome Browser
Location (GRCh38)
2:196200971-196592611
UCSC Genome Browser Search in Marker Scope
Host gene
HECW2
Host category
mRNA
Forensic tag(s)
Drug abuse diagnoses
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_HECW2_0004900 Exon-Exon chr2:197118644-197184628 chr2:196253920-196319904 2544 nt 0.5515
hsa_HECW2_0005000 Intron-Exon-Intron chr2:197118644-197184649 chr2:196253920-196319925 2565 nt 0.5497
hsa_HECW2_0005400 Exon-Exon chr2:197118644-197298182 chr2:196253920-196433458 437 nt 0.5492
hsa_HECW2_0005500 Intron-Intron chr2:197119851-197120671 chr2:196255127-196255947 821 nt 0.3727
hsa_HECW2_0005900 Exon-Exon chr2:197122547-197157474 chr2:196257823-196292750 283 nt 0.4770
hsa_HECW2_0006000 Exon-Exon chr2:197122547-197189873 chr2:196257823-196325149 84 nt 0.4881
hsa_HECW2_0006900 Exon-Exon chr2:197135917-197138847 chr2:196271193-196274123 200 nt 0.4600
hsa_HECW2_0007000 Exon-Exon chr2:197135917-197143401 chr2:196271193-196278677 350 nt 0.5000
hsa_HECW2_0007200 Intron-Exon-Intron chr2:197135917-197163489 chr2:196271193-196298765 109 nt 0.4404
hsa_HECW2_0007100 Exon-Exon chr2:197135917-197171336 chr2:196271193-196306612 646 nt 0.5155
Showing 81 to 90 of 147 entries
Forensic Context

A study in rodents demonstrated that the circHECW2 is involved in Endothelial-mesenchymal-transition (EndoMT) during methamphetamine abuse, where it inhibits the activity of endogenous miR30D sponge, activating downstream ATG5 and leading to blood-brain barrier damage [Gu et al. DOI:10.1007/s11010-021-04160-y].