Basic Information

Symbol
circHIPK3
RNA Class
circRNA
Alias
Homeodomain Interacting Protein Kinase 3 DYRK6 FIST3 PKY Homeodomain-Interacting Protein Kinase 3 YAK1 Androgen Receptor-Interacting Nuclear Protein Kinase Fas-Interacting Serine/Threonine-Protein Kinase Homolog Of Protein Kinase YAK1 EC 2.7.11.1 ANPK FIST
Location (GRCh37)
11:33273750-33377913 UCSC Genome Browser
Location (GRCh38)
11:33252204-33356367
UCSC Genome Browser Search in Marker Scope
Host gene
HIPK3
Host category
mRNA
Forensic tag(s)
Sudden death from CNS diseases Sudden cardiac death diagnosis
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_HIPK3_0002600 Exon-Exon chr11:33307959-33309057 chr11:33286413-33287511 1099 nt 0.4204
hsa_HIPK3_0000500 Exon-Exon chr11:33279168-33309057 chr11:33257622-33287511 1367 nt 0.4799
hsa_HIPK3_0000600 Exon-Exon chr11:33279168-33369559 chr11:33257622-33348013 2576 nt 0.4573
hsa_HIPK3_0002500 Exon-Exon chr11:33307959-33308498 chr11:33286413-33286952 540 nt 0.4519
hsa_HIPK3_0002600 Exon-Exon chr11:33307959-33309057 chr11:33286413-33287511 1099 nt 0.4204
hsa_HIPK3_0002700 Exon-Exon chr11:33307959-33350179 chr11:33286413-33328633 1223 nt 0.4244
hsa_HIPK3_0002800 Exon-Exon chr11:33307959-33358740 chr11:33286413-33337194 1343 nt 0.4185
hsa_HIPK3_0002900 Exon-Exon chr11:33307959-33360389 chr11:33286413-33338843 1430 nt 0.4182
hsa_HIPK3_0003000 Exon-Exon chr11:33307959-33361080 chr11:33286413-33339534 1615 nt 0.4136
hsa_HIPK3_0003100 Exon-Exon chr11:33307959-33362673 chr11:33286413-33341127 1775 nt 0.4068
Showing 1 to 10 of 213 entries
Forensic Context

A study in humans and other model organisms demonstrated that the circHIPK3 is abundantly expressed in brain, cerebellum, heart, colon, lung, and stomach, where it is involved in cell proliferation, migration, angiogenesis, and tumorigenesis [Misir et al. DOI:10.1038/s41418-022-00948-7]. In neural tissue and glioma, it functions as a miRNA sponge for miR-124-3p to derepress STAT3, thereby promoting glioma invasiveness [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746]. A study in humans demonstrated that the circHIPK3 was significantly elevated in peripheral blood leukocytes of coronary artery disease patients, showing an area under the curve of 0.68 with a sensitivity of 0.66 and a specificity of 0.71 [Tian et al. DOI:10.3390/molecules26041155].