Basic Information

Symbol
circHIPK3
RNA Class
circRNA
Alias
Homeodomain Interacting Protein Kinase 3 DYRK6 FIST3 PKY Homeodomain-Interacting Protein Kinase 3 YAK1 Androgen Receptor-Interacting Nuclear Protein Kinase Fas-Interacting Serine/Threonine-Protein Kinase Homolog Of Protein Kinase YAK1 EC 2.7.11.1 ANPK FIST
Location (GRCh37)
11:33273750-33377913 UCSC Genome Browser
Location (GRCh38)
11:33252204-33356367
UCSC Genome Browser Search in Marker Scope
Host gene
HIPK3
Host category
mRNA
Forensic tag(s)
Sudden death from CNS diseases Sudden cardiac death diagnosis
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_HIPK3_0006800 Exon-Exon chr11:33358621-33369559 chr11:33337075-33348013 120 nt 0.3583
hsa_HIPK3_0006600 Exon-Exon chr11:33358621-33370364 chr11:33337075-33348818 1445 nt 0.4242
hsa_HIPK3_0006900 Exon-Exon chr11:33358621-33370833 chr11:33337075-33349287 141 nt 0.4681
hsa_HIPK3_0007000 Intron-Intron chr11:33358741-33360261 chr11:33337195-33338715 1521 nt 0.4287
hsa_HIPK3_0007100 Intron-Exon-Intron chr11:33359496-33363369 chr11:33337950-33341823 1500 nt 0.3760
hsa_HIPK3_0007400 Exon-Exon chr11:33360896-33363232 chr11:33339350-33341686 185 nt 0.3784
hsa_HIPK3_0007300 Exon-Exon chr11:33360896-33369559 chr11:33339350-33348013 878 nt 0.4396
hsa_HIPK3_0007500 Exon-Exon chr11:33360896-33373811 chr11:33339350-33352265 128 nt 0.4453
hsa_HIPK3_0007600 Exon-Exon chr11:33360921-33363181 chr11:33339375-33341635 393 nt 0.3791
hsa_HIPK3_0008000 Exon-Exon chr11:33362514-33368960 chr11:33340968-33347414 166 nt 0.3434
Showing 101 to 110 of 213 entries
Forensic Context

A study in humans and other model organisms demonstrated that the circHIPK3 is abundantly expressed in brain, cerebellum, heart, colon, lung, and stomach, where it is involved in cell proliferation, migration, angiogenesis, and tumorigenesis [Misir et al. DOI:10.1038/s41418-022-00948-7]. In neural tissue and glioma, it functions as a miRNA sponge for miR-124-3p to derepress STAT3, thereby promoting glioma invasiveness [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746]. A study in humans demonstrated that the circHIPK3 was significantly elevated in peripheral blood leukocytes of coronary artery disease patients, showing an area under the curve of 0.68 with a sensitivity of 0.66 and a specificity of 0.71 [Tian et al. DOI:10.3390/molecules26041155].