Basic Information

Symbol
circHIPK3
RNA Class
circRNA
Alias
Homeodomain Interacting Protein Kinase 3 DYRK6 FIST3 PKY Homeodomain-Interacting Protein Kinase 3 YAK1 Androgen Receptor-Interacting Nuclear Protein Kinase Fas-Interacting Serine/Threonine-Protein Kinase Homolog Of Protein Kinase YAK1 EC 2.7.11.1 ANPK FIST
Location (GRCh37)
11:33273750-33377913 UCSC Genome Browser
Location (GRCh38)
11:33252204-33356367
UCSC Genome Browser Search in Marker Scope
Host gene
HIPK3
Host category
mRNA
Forensic tag(s)
Sudden death from CNS diseases Sudden cardiac death diagnosis
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_chr11_0271100 Intergenic-Intergenic chr11:33373299-33374710 chr11:33351753-33353164 292 nt 0.4555
hsa_chr11_0271200 Intergenic-Intergenic chr11:33374900-33375433 chr11:33353354-33353887 534 nt 0.3745
hsa_chr11_0271300 Intergenic-Intergenic chr11:33374900-33375697 chr11:33353354-33354151 798 nt 0.3672
hsa_chr11_0271400 Intergenic-Intergenic chr11:33375009-33375739 chr11:33353463-33354193 731 nt 0.3502
hsa_HIPK3_0009000 Exon-Exon chr11:33375804-33376421 chr11:33354258-33354875 618 nt 0.3350
hsa_HIPK3_0009100 Exon-Exon chr11:33376540-33376676 chr11:33354994-33355130 137 nt 0.3212
hsa_chr11_0271500 Intergenic-Intergenic chr11:33377287-33377913 chr11:33355741-33356367 627 nt 0.2839
hsa_HIPK3_0000200 Intergenic-Exon chr11:33273750-33309057 chr11:33252204-33287511 250 nt 0.3760
hsa_HIPK3_0000300 Intergenic-Exon chr11:33273750-33350179 chr11:33252204-33328633 250 nt 0.3920
hsa_HIPK3_0000400 Intergenic-Exon chr11:33274249-33309057 chr11:33252703-33287511 250 nt 0.3400
Showing 121 to 130 of 213 entries
Forensic Context

A study in humans and other model organisms demonstrated that the circHIPK3 is abundantly expressed in brain, cerebellum, heart, colon, lung, and stomach, where it is involved in cell proliferation, migration, angiogenesis, and tumorigenesis [Misir et al. DOI:10.1038/s41418-022-00948-7]. In neural tissue and glioma, it functions as a miRNA sponge for miR-124-3p to derepress STAT3, thereby promoting glioma invasiveness [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746]. A study in humans demonstrated that the circHIPK3 was significantly elevated in peripheral blood leukocytes of coronary artery disease patients, showing an area under the curve of 0.68 with a sensitivity of 0.66 and a specificity of 0.71 [Tian et al. DOI:10.3390/molecules26041155].