Basic Information

Symbol
circHIPK3
RNA Class
circRNA
Alias
Homeodomain Interacting Protein Kinase 3 DYRK6 FIST3 PKY Homeodomain-Interacting Protein Kinase 3 YAK1 Androgen Receptor-Interacting Nuclear Protein Kinase Fas-Interacting Serine/Threonine-Protein Kinase Homolog Of Protein Kinase YAK1 EC 2.7.11.1 ANPK FIST
Location (GRCh37)
11:33273750-33377913 UCSC Genome Browser
Location (GRCh38)
11:33252204-33356367
UCSC Genome Browser Search in Marker Scope
Host gene
HIPK3
Host category
mRNA
Forensic tag(s)
Sudden death from CNS diseases Sudden cardiac death diagnosis
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_HIPK3_0000700 Exon-Exon chr11:33279176-33279435 chr11:33257630-33257889 260 nt 0.7231
hsa_HIPK3_0000800 Exon-Exon chr11:33279301-33375098 chr11:33257755-33353552 250 nt 0.4880
hsa_HIPK3_0000900 Intron-Exon-Intron chr11:33281985-33309057 chr11:33260439-33287511 107 nt 0.3178
hsa_chr11_0270000 Intergenic-Intergenic chr11:33285111-33285295 chr11:33263565-33263749 185 nt 0.4324
hsa_HIPK3_0001000 Intron-Intron chr11:33287560-33289097 chr11:33266014-33267551 1538 nt 0.3979
hsa_chr11_0270100 Intergenic-Intergenic chr11:33288751-33290059 chr11:33267205-33268513 1309 nt 0.4691
hsa_HIPK3_0001100 Intron-Intron chr11:33288937-33292843 chr11:33267391-33271297 250 nt 0.3000
hsa_chr11_0270200 Intergenic-Intergenic chr11:33289724-33290108 chr11:33268178-33268562 385 nt 0.4130
hsa_HIPK3_0001200 Intron-Intron chr11:33290813-33301395 chr11:33269267-33279849 250 nt 0.3720
hsa_chr11_0270300 Intergenic-Intergenic chr11:33290823-33291082 chr11:33269277-33269536 260 nt 0.3577
Showing 131 to 140 of 213 entries
Forensic Context

A study in humans and other model organisms demonstrated that the circHIPK3 is abundantly expressed in brain, cerebellum, heart, colon, lung, and stomach, where it is involved in cell proliferation, migration, angiogenesis, and tumorigenesis [Misir et al. DOI:10.1038/s41418-022-00948-7]. In neural tissue and glioma, it functions as a miRNA sponge for miR-124-3p to derepress STAT3, thereby promoting glioma invasiveness [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746]. A study in humans demonstrated that the circHIPK3 was significantly elevated in peripheral blood leukocytes of coronary artery disease patients, showing an area under the curve of 0.68 with a sensitivity of 0.66 and a specificity of 0.71 [Tian et al. DOI:10.3390/molecules26041155].