Basic Information

Symbol
circHIPK3
RNA Class
circRNA
Alias
Homeodomain Interacting Protein Kinase 3 DYRK6 FIST3 PKY Homeodomain-Interacting Protein Kinase 3 YAK1 Androgen Receptor-Interacting Nuclear Protein Kinase Fas-Interacting Serine/Threonine-Protein Kinase Homolog Of Protein Kinase YAK1 EC 2.7.11.1 ANPK FIST
Location (GRCh37)
11:33273750-33377913 UCSC Genome Browser
Location (GRCh38)
11:33252204-33356367
UCSC Genome Browser Search in Marker Scope
Host gene
HIPK3
Host category
mRNA
Forensic tag(s)
Sudden death from CNS diseases Sudden cardiac death diagnosis
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_HIPK3_0005200 Intron-Intron chr11:33309986-33316176 chr11:33288440-33294630 250 nt 0.2320
hsa_chr11_0270700 Intergenic-Intergenic chr11:33318722-33320940 chr11:33297176-33299394 2219 nt 0.4579
hsa_chr11_0270800 Intergenic-Intergenic chr11:33322396-33323211 chr11:33300850-33301665 816 nt 0.3836
hsa_chr11_0270900 Intergenic-Intergenic chr11:33323205-33331961 chr11:33301659-33310415 250 nt 0.4120
hsa_HIPK3_0005800 Exon-Exon chr11:33350056-33360389 chr11:33328510-33338843 440 nt 0.4114
hsa_HIPK3_0005400 Exon-Exon chr11:33350056-33361080 chr11:33328510-33339534 516 nt 0.3992
hsa_HIPK3_0005900 Exon-Exon chr11:33350056-33362673 chr11:33328510-33341127 371 nt 0.3962
hsa_HIPK3_0005500 Exon-Exon chr11:33350056-33368960 chr11:33328510-33347414 922 nt 0.4078
hsa_HIPK3_0005600 Exon-Exon chr11:33350056-33369559 chr11:33328510-33348013 1209 nt 0.4318
hsa_HIPK3_0005700 Exon-Exon chr11:33350056-33370364 chr11:33328510-33348818 1569 nt 0.4270
Showing 171 to 180 of 213 entries
Forensic Context

A study in humans and other model organisms demonstrated that the circHIPK3 is abundantly expressed in brain, cerebellum, heart, colon, lung, and stomach, where it is involved in cell proliferation, migration, angiogenesis, and tumorigenesis [Misir et al. DOI:10.1038/s41418-022-00948-7]. In neural tissue and glioma, it functions as a miRNA sponge for miR-124-3p to derepress STAT3, thereby promoting glioma invasiveness [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746]. A study in humans demonstrated that the circHIPK3 was significantly elevated in peripheral blood leukocytes of coronary artery disease patients, showing an area under the curve of 0.68 with a sensitivity of 0.66 and a specificity of 0.71 [Tian et al. DOI:10.3390/molecules26041155].