Basic Information

Symbol
circHIPK3
RNA Class
circRNA
Alias
Homeodomain Interacting Protein Kinase 3 DYRK6 FIST3 PKY Homeodomain-Interacting Protein Kinase 3 YAK1 Androgen Receptor-Interacting Nuclear Protein Kinase Fas-Interacting Serine/Threonine-Protein Kinase Homolog Of Protein Kinase YAK1 EC 2.7.11.1 ANPK FIST
Location (GRCh37)
11:33273750-33377913 UCSC Genome Browser
Location (GRCh38)
11:33252204-33356367
UCSC Genome Browser Search in Marker Scope
Host gene
HIPK3
Host category
mRNA
Forensic tag(s)
Sudden death from CNS diseases Sudden cardiac death diagnosis
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_HIPK3_0006000 Exon-Exon chr11:33350100-33362673 chr11:33328554-33341127 632 nt 0.3813
hsa_HIPK3_0006100 Intron-Intron chr11:33352487-33353202 chr11:33330941-33331656 716 nt 0.4749
hsa_HIPK3_0006200 Intron-Intron chr11:33357112-33357369 chr11:33335566-33335823 258 nt 0.3605
hsa_HIPK3_0006300 Intron-Exon-Intron chr11:33357204-33363232 chr11:33335658-33341686 2093 nt 0.3875
hsa_HIPK3_0006700 Exon-Exon chr11:33358621-33361080 chr11:33337075-33339534 191 nt 0.3770
hsa_HIPK3_0006500 Exon-Exon chr11:33358621-33362673 chr11:33337075-33341127 552 nt 0.3678
hsa_HIPK3_0006800 Exon-Exon chr11:33358621-33369559 chr11:33337075-33348013 120 nt 0.3583
hsa_HIPK3_0006600 Exon-Exon chr11:33358621-33370364 chr11:33337075-33348818 1445 nt 0.4242
hsa_HIPK3_0006900 Exon-Exon chr11:33358621-33370833 chr11:33337075-33349287 141 nt 0.4681
hsa_HIPK3_0007000 Intron-Intron chr11:33358741-33360261 chr11:33337195-33338715 1521 nt 0.4287
Showing 181 to 190 of 213 entries
Forensic Context

A study in humans and other model organisms demonstrated that the circHIPK3 is abundantly expressed in brain, cerebellum, heart, colon, lung, and stomach, where it is involved in cell proliferation, migration, angiogenesis, and tumorigenesis [Misir et al. DOI:10.1038/s41418-022-00948-7]. In neural tissue and glioma, it functions as a miRNA sponge for miR-124-3p to derepress STAT3, thereby promoting glioma invasiveness [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746]. A study in humans demonstrated that the circHIPK3 was significantly elevated in peripheral blood leukocytes of coronary artery disease patients, showing an area under the curve of 0.68 with a sensitivity of 0.66 and a specificity of 0.71 [Tian et al. DOI:10.3390/molecules26041155].