Basic Information

Symbol
circHIPK3
RNA Class
circRNA
Alias
Homeodomain Interacting Protein Kinase 3 DYRK6 FIST3 PKY Homeodomain-Interacting Protein Kinase 3 YAK1 Androgen Receptor-Interacting Nuclear Protein Kinase Fas-Interacting Serine/Threonine-Protein Kinase Homolog Of Protein Kinase YAK1 EC 2.7.11.1 ANPK FIST
Location (GRCh37)
11:33273750-33377913 UCSC Genome Browser
Location (GRCh38)
11:33252204-33356367
UCSC Genome Browser Search in Marker Scope
Host gene
HIPK3
Host category
mRNA
Forensic tag(s)
Sudden death from CNS diseases Sudden cardiac death diagnosis
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_HIPK3_0003200 Exon-Exon chr11:33307959-33363232 chr11:33286413-33341686 1899 nt 0.4113
hsa_HIPK3_0003300 Exon-Exon chr11:33307959-33368960 chr11:33286413-33347414 2021 nt 0.4146
hsa_HIPK3_0003400 Exon-Exon chr11:33307959-33369559 chr11:33286413-33348013 2308 nt 0.4263
hsa_HIPK3_0003500 Exon-Exon chr11:33307959-33370833 chr11:33286413-33349287 2809 nt 0.4265
hsa_HIPK3_0003600 Exon-Exon chr11:33307959-33373389 chr11:33286413-33351843 250 nt 0.3640
hsa_HIPK3_0005300 Exon-Exon chr11:33350056-33363232 chr11:33328510-33341686 800 nt 0.3988
hsa_HIPK3_0006400 Exon-Exon chr11:33358621-33363232 chr11:33337075-33341686 676 nt 0.3876
hsa_HIPK3_0007200 Exon-Exon chr11:33360303-33363232 chr11:33338757-33341686 556 nt 0.3939
hsa_HIPK3_0007700 Exon-Exon chr11:33362514-33363232 chr11:33340968-33341686 284 nt 0.3979
hsa_HIPK3_0008100 Exon-Exon chr11:33363109-33369559 chr11:33341563-33348013 533 nt 0.4916
Showing 11 to 20 of 213 entries
Forensic Context

A study in humans and other model organisms demonstrated that the circHIPK3 is abundantly expressed in brain, cerebellum, heart, colon, lung, and stomach, where it is involved in cell proliferation, migration, angiogenesis, and tumorigenesis [Misir et al. DOI:10.1038/s41418-022-00948-7]. In neural tissue and glioma, it functions as a miRNA sponge for miR-124-3p to derepress STAT3, thereby promoting glioma invasiveness [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746]. A study in humans demonstrated that the circHIPK3 was significantly elevated in peripheral blood leukocytes of coronary artery disease patients, showing an area under the curve of 0.68 with a sensitivity of 0.66 and a specificity of 0.71 [Tian et al. DOI:10.3390/molecules26041155].