Basic Information

Symbol
circHIPK3
RNA Class
circRNA
Alias
Homeodomain Interacting Protein Kinase 3 DYRK6 FIST3 PKY Homeodomain-Interacting Protein Kinase 3 YAK1 Androgen Receptor-Interacting Nuclear Protein Kinase Fas-Interacting Serine/Threonine-Protein Kinase Homolog Of Protein Kinase YAK1 EC 2.7.11.1 ANPK FIST
Location (GRCh37)
11:33273750-33377913 UCSC Genome Browser
Location (GRCh38)
11:33252204-33356367
UCSC Genome Browser Search in Marker Scope
Host gene
HIPK3
Host category
mRNA
Forensic tag(s)
Sudden death from CNS diseases Sudden cardiac death diagnosis
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_HIPK3_0001800 Intron-Exon-Intron chr11:33301303-33309057 chr11:33279757-33287511 234 nt 0.4829
hsa_HIPK3_0001900 Intron-Exon-Intron chr11:33301303-33327555 chr11:33279757-33306009 48 nt 0.5000
hsa_HIPK3_0002000 Intron-Intron chr11:33302759-33304099 chr11:33281213-33282553 1341 nt 0.3818
hsa_HIPK3_0002100 Intron-Intron chr11:33303842-33307412 chr11:33282296-33285866 250 nt 0.3680
hsa_HIPK3_0002200 Intron-Intron chr11:33305621-33306545 chr11:33284075-33284999 925 nt 0.3632
hsa_HIPK3_0002300 Intron-Exon-Intron chr11:33305759-33309057 chr11:33284213-33287511 250 nt 0.3080
hsa_HIPK3_0002400 Intron-Exon-Intron chr11:33307532-33309785 chr11:33285986-33288239 2254 nt 0.3767
hsa_chr11_0270500 Intergenic-Intergenic chr11:33307552-33309780 chr11:33286006-33288234 2229 nt 0.3742
hsa_HIPK3_0003700 Intron-Exon-Intron chr11:33307959-33321973 chr11:33286413-33300427 250 nt 0.3360
hsa_HIPK3_0003900 Intron-Exon-Intron chr11:33307959-33327555 chr11:33286413-33306009 144 nt 0.5486
Showing 61 to 70 of 213 entries
Forensic Context

A study in humans and other model organisms demonstrated that the circHIPK3 is abundantly expressed in brain, cerebellum, heart, colon, lung, and stomach, where it is involved in cell proliferation, migration, angiogenesis, and tumorigenesis [Misir et al. DOI:10.1038/s41418-022-00948-7]. In neural tissue and glioma, it functions as a miRNA sponge for miR-124-3p to derepress STAT3, thereby promoting glioma invasiveness [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746]. A study in humans demonstrated that the circHIPK3 was significantly elevated in peripheral blood leukocytes of coronary artery disease patients, showing an area under the curve of 0.68 with a sensitivity of 0.66 and a specificity of 0.71 [Tian et al. DOI:10.3390/molecules26041155].