Basic Information

Symbol
circHIPK3
RNA Class
circRNA
Alias
Homeodomain Interacting Protein Kinase 3 DYRK6 FIST3 PKY Homeodomain-Interacting Protein Kinase 3 YAK1 Androgen Receptor-Interacting Nuclear Protein Kinase Fas-Interacting Serine/Threonine-Protein Kinase Homolog Of Protein Kinase YAK1 EC 2.7.11.1 ANPK FIST
Location (GRCh37)
11:33273750-33377913 UCSC Genome Browser
Location (GRCh38)
11:33252204-33356367
UCSC Genome Browser Search in Marker Scope
Host gene
HIPK3
Host category
mRNA
Forensic tag(s)
Sudden death from CNS diseases Sudden cardiac death diagnosis
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_HIPK3_0004000 Intron-Exon-Intron chr11:33307959-33339231 chr11:33286413-33317685 36 nt 0.3333
hsa_HIPK3_0004100 Intron-Exon-Intron chr11:33307959-33339892 chr11:33286413-33318346 96 nt 0.5521
hsa_HIPK3_0003800 Exon-Exon chr11:33307959-33369774 chr11:33286413-33348228 2371 nt 0.4251
hsa_HIPK3_0004200 Exon-Exon chr11:33308009-33309057 chr11:33286463-33287511 1049 nt 0.4194
hsa_HIPK3_0004300 Exon-Exon chr11:33308069-33308590 chr11:33286523-33287044 522 nt 0.4521
hsa_HIPK3_0004400 Exon-Exon chr11:33308069-33309057 chr11:33286523-33287511 989 nt 0.4196
hsa_HIPK3_0004500 Exon-Exon chr11:33308229-33308498 chr11:33286683-33286952 270 nt 0.4926
hsa_HIPK3_0004600 Exon-Exon chr11:33308229-33309057 chr11:33286683-33287511 829 nt 0.4234
hsa_HIPK3_0004700 Exon-Exon chr11:33308229-33363232 chr11:33286683-33341686 1629 nt 0.4113
hsa_HIPK3_0004800 Exon-Exon chr11:33308240-33308498 chr11:33286694-33286952 259 nt 0.4942
Showing 71 to 80 of 213 entries
Forensic Context

A study in humans and other model organisms demonstrated that the circHIPK3 is abundantly expressed in brain, cerebellum, heart, colon, lung, and stomach, where it is involved in cell proliferation, migration, angiogenesis, and tumorigenesis [Misir et al. DOI:10.1038/s41418-022-00948-7]. In neural tissue and glioma, it functions as a miRNA sponge for miR-124-3p to derepress STAT3, thereby promoting glioma invasiveness [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746]. A study in humans demonstrated that the circHIPK3 was significantly elevated in peripheral blood leukocytes of coronary artery disease patients, showing an area under the curve of 0.68 with a sensitivity of 0.66 and a specificity of 0.71 [Tian et al. DOI:10.3390/molecules26041155].