Basic Information

Symbol
circHIPK3
RNA Class
circRNA
Alias
Homeodomain Interacting Protein Kinase 3 DYRK6 FIST3 PKY Homeodomain-Interacting Protein Kinase 3 YAK1 Androgen Receptor-Interacting Nuclear Protein Kinase Fas-Interacting Serine/Threonine-Protein Kinase Homolog Of Protein Kinase YAK1 EC 2.7.11.1 ANPK FIST
Location (GRCh37)
11:33273750-33377913 UCSC Genome Browser
Location (GRCh38)
11:33252204-33356367
UCSC Genome Browser Search in Marker Scope
Host gene
HIPK3
Host category
mRNA
Forensic tag(s)
Sudden death from CNS diseases Sudden cardiac death diagnosis
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_chr11_0270600 Intergenic-Intergenic chr11:33308280-33308701 chr11:33286734-33287155 422 nt 0.4336
hsa_HIPK3_0004900 Exon-Exon chr11:33308322-33308498 chr11:33286776-33286952 177 nt 0.4689
hsa_HIPK3_0005000 Exon-Exon chr11:33308322-33308672 chr11:33286776-33287126 351 nt 0.4302
hsa_HIPK3_0005100 Exon-Exon chr11:33308836-33309048 chr11:33287290-33287502 213 nt 0.4225
hsa_HIPK3_0005200 Intron-Intron chr11:33309986-33316176 chr11:33288440-33294630 250 nt 0.2320
hsa_chr11_0270700 Intergenic-Intergenic chr11:33318722-33320940 chr11:33297176-33299394 2219 nt 0.4579
hsa_chr11_0270800 Intergenic-Intergenic chr11:33322396-33323211 chr11:33300850-33301665 816 nt 0.3836
hsa_chr11_0270900 Intergenic-Intergenic chr11:33323205-33331961 chr11:33301659-33310415 250 nt 0.4120
hsa_HIPK3_0005800 Exon-Exon chr11:33350056-33360389 chr11:33328510-33338843 440 nt 0.4114
hsa_HIPK3_0005400 Exon-Exon chr11:33350056-33361080 chr11:33328510-33339534 516 nt 0.3992
Showing 81 to 90 of 213 entries
Forensic Context

A study in humans and other model organisms demonstrated that the circHIPK3 is abundantly expressed in brain, cerebellum, heart, colon, lung, and stomach, where it is involved in cell proliferation, migration, angiogenesis, and tumorigenesis [Misir et al. DOI:10.1038/s41418-022-00948-7]. In neural tissue and glioma, it functions as a miRNA sponge for miR-124-3p to derepress STAT3, thereby promoting glioma invasiveness [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746]. A study in humans demonstrated that the circHIPK3 was significantly elevated in peripheral blood leukocytes of coronary artery disease patients, showing an area under the curve of 0.68 with a sensitivity of 0.66 and a specificity of 0.71 [Tian et al. DOI:10.3390/molecules26041155].