Forensic RNA Knowledge Base

Basic Information

Symbol

circHOMER1

RNA Class

circRNA

Alias

Homer Scaffold Protein 1 SYN47 Ves-1 Homer Scaffolding Protein 1 Homer Protein Homolog 1 HOMER-1B Homer-1 Homer, Neuronal Immediate Early Gene, 1 Homer Homolog 1 (Drosophila) Homer Homolog 1 HOMER1A HOMER1B HOMER1C HOMER

Location (GRCh37)

5:78659350-78808917 UCSC Genome Browser

Location (GRCh38)

5:79363527-79513094

UCSC Genome Browser Search in Marker Scope

Host gene

HOMER1

Host category

mRNA

Forensic tag(s)

Drug abuse diagnoses

External database

circbank

Transcripts

ID	Type	Location (GRCh37)	Location (GRCh38)	Length	GC content
hsa_chr5_0606800	Intergenic-Intergenic	chr5:78793130-78793837	chr5:79497307-79498014	708 nt	0.4407
hsa_HOMER1_0005200	Intron-Intron	chr5:78794262-78794410	chr5:79498439-79498587	149 nt	0.3826
hsa_chr5_0606900	Intergenic-Intergenic	chr5:78802033-78802971	chr5:79506210-79507148	939 nt	0.4207
hsa_chr5_0607000	Intergenic-Intergenic	chr5:78802040-78802971	chr5:79506217-79507148	932 nt	0.4206

Showing 111 to 114 of 114 entries

Forensic Context

A study in mice demonstrated that the circHOMER1 is upregulated in primary cortical neurons and multiple brain regions, including the hippocampus, prefrontal cortex, ventral tegmental area, and nucleus accumbens, following methamphetamine exposure, where it is associated with methamphetamine-induced toxicity and conditioned place preference scores [Daws et al. DOI:10.1016/j.mcn.2023.103841]. The circHOMER1 is recognized as a synaptically-enriched circRNA that modulates structural changes at synapses during neuronal plasticity and development [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746]. A study in humans and mice demonstrated that circHomer 1, a circular RNA, regulates neuronal plasticity and structural changes in the synapse during development [Sema Misir et al. DOI:10.1038/s41418-022-00948-7].