Basic Information
Symbol
circHTRA1
RNA Class
circRNA
Alias
HtrA Serine Peptidase 1
IGFBP5-Protease
PRSS11
ARMD7
HtrA
High-Temperature Requirement A Serine Peptidase 1
Protease, Serine, 11 (IGF Binding)
Serine Protease HTRA1
L56
Serine Protease 11
EC 3.4.21.108
EC 3.4.21.-
EC 3.4.21
CADASIL2
CARASIL2
CARASIL
ORF480
HTRA
Location (GRCh37)
10:124221041-124274424
UCSC Genome Browser
Location (GRCh38)
10:122461525-122514908
Host gene
HTRA1
Host category
mRNA
Forensic tag(s)
Mechanical injury analysis
Wound age identification
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_HTRA1_0000100 | Exon-Exon | chr10:124221041-124274424 | chr10:122461525-122514908 | 2120 nt | 0.5844 |
Forensic Context
A study in human severe traumatic brain injury (TBI) patients identified 126 differentially expressed circular RNAs (circRNAs) in brain tissue, with 64 upregulated and 62 downregulated [Li et al. DOI:10.3389/fneur.2022.1086553]. The circRNA hsa_circ_0020269 (circHtra1) is significantly upregulated after brain insults and its raised expression in human plasma is positively correlated with injury severity, indicating its prospective role as a biomarker [Li et al. DOI:10.1016/j.neuint.2023.105643].