Basic Information

Symbol
circITCH
RNA Class
circRNA
Alias
Itchy E3 Ubiquitin Protein Ligase AIP4 HECT-Type E3 Ubiquitin Transferase Itchy Homolog E3 Ubiquitin-Protein Ligase Itchy Homolog NFE2-Associated Polypeptide 1 NAPP1 Itchy (Mouse Homolog) E3 Ubiquitin Protein Ligase Itchy E3 Ubiquitin Protein Ligase Homolog (Mouse) Itchy E3 Ubiquitin Protein Ligase Homolog Atrophin-1 Interacting Protein 4 Atrophin-1-Interacting Protein 4 EC 2.3.2.26 EC 6.3.2 ADMFD AIF4 Itch
Location (GRCh37)
20:32951062-33099197 UCSC Genome Browser
Location (GRCh38)
20:34363256-34511392
UCSC Genome Browser Search in Marker Scope
Host gene
ITCH
Host category
mRNA
Forensic tag(s)
Other applications
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_ITCH_0000200 Exon-Exon chr20:32951062-32981687 chr20:34363256-34393881 262 nt 0.5382
hsa_ITCH_0000300 Exon-Exon chr20:32951062-33037285 chr20:34363256-34449480 1402 nt 0.4572
hsa_ITCH_0001000 Exon-Exon chr20:32957200-32981687 chr20:34369394-34393881 168 nt 0.4702
hsa_ITCH_0001100 Exon-Exon chr20:32957200-32996598 chr20:34369394-34408792 310 nt 0.4419
hsa_ITCH_0001200 Exon-Exon chr20:32957200-33001685 chr20:34369394-34413879 573 nt 0.4136
hsa_ITCH_0001300 Exon-Exon chr20:32957200-33028149 chr20:34369394-34440344 1090 nt 0.4495
hsa_ITCH_0002100 Exon-Exon chr20:32957200-33059320 chr20:34369394-34471515 1667 nt 0.4397
hsa_ITCH_0002200 Exon-Exon chr20:32957200-33068537 chr20:34369394-34480732 2050 nt 0.4302
hsa_ITCH_0004800 Exon-Exon chr20:32981597-33001685 chr20:34393791-34413879 496 nt 0.4012
hsa_ITCH_0005500 Exon-Exon chr20:32981597-33012331 chr20:34393791-34424525 542 nt 0.4059
Showing 1 to 10 of 255 entries
Forensic Context

A review consolidating research in humans and model organisms indicates that the circITCH functions as a tumor suppressor in glioma by sponging miR-214 to allow expression of ubiquitin-protein ligase E3, thereby suppressing proliferation and preventing apoptosis, while also targeting the Wnt/β-catenin pathway [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746]. In oesophageal squamous cell carcinoma, the circITCH is downregulated and increases ITCH expression to inhibit the Wnt/β-catenin pathway [Lee et al. DOI:10.1016/j.biopha.2018.12.052]. circITCH hsa_circ_0001141 (circITCH) was found to be lower in the hearts of cancer patients suffering from doxorubicin-induced cardiomyopathy compared to those with dilated cardiomyopathy, hypertrophic cardiomyopathy, and healthy donors, and its expression ameliorates doxorubicin-induced cardiomyocyte injury [Tian et al. DOI:10.3390/molecules26041155].