Basic Information

Symbol
circITCH
RNA Class
circRNA
Alias
Itchy E3 Ubiquitin Protein Ligase AIP4 HECT-Type E3 Ubiquitin Transferase Itchy Homolog E3 Ubiquitin-Protein Ligase Itchy Homolog NFE2-Associated Polypeptide 1 NAPP1 Itchy (Mouse Homolog) E3 Ubiquitin Protein Ligase Itchy E3 Ubiquitin Protein Ligase Homolog (Mouse) Itchy E3 Ubiquitin Protein Ligase Homolog Atrophin-1 Interacting Protein 4 Atrophin-1-Interacting Protein 4 EC 2.3.2.26 EC 6.3.2 ADMFD AIF4 Itch
Location (GRCh37)
20:32951062-33099197 UCSC Genome Browser
Location (GRCh38)
20:34363256-34511392
UCSC Genome Browser Search in Marker Scope
Host gene
ITCH
Host category
mRNA
Forensic tag(s)
Other applications
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_ITCH_0003100 Intron-Exon-Intron chr20:32980327-33012331 chr20:34392521-34424525 46 nt 0.4565
hsa_ITCH_0002900 Intron-Exon-Intron chr20:32980327-33030108 chr20:34392521-34442303 2379 nt 0.4300
hsa_ITCH_0003200 Intron-Exon-Intron chr20:32980373-32996598 chr20:34392567-34408792 1457 nt 0.4207
hsa_ITCH_0003300 Intron-Exon-Intron chr20:32980373-33014060 chr20:34392567-34426254 102 nt 0.3529
hsa_ITCH_0003500 Intron-Exon-Intron chr20:32980539-32981687 chr20:34392733-34393881 1149 nt 0.4386
hsa_ITCH_0003600 Intron-Exon-Intron chr20:32980539-33001685 chr20:34392733-34413879 1554 nt 0.4260
hsa_ITCH_0003400 Intron-Exon-Intron chr20:32980539-33045279 chr20:34392733-34457474 2497 nt 0.4445
hsa_ITCH_0004200 Intron-Exon-Intron chr20:32980543-32981687 chr20:34392737-34393881 1145 nt 0.4384
hsa_ITCH_0004300 Intron-Exon-Intron chr20:32980543-32996598 chr20:34392737-34408792 1287 nt 0.4351
hsa_ITCH_0003700 Intron-Exon-Intron chr20:32980543-33030108 chr20:34392737-34442303 2163 nt 0.4438
Showing 91 to 100 of 255 entries
Forensic Context

A review consolidating research in humans and model organisms indicates that the circITCH functions as a tumor suppressor in glioma by sponging miR-214 to allow expression of ubiquitin-protein ligase E3, thereby suppressing proliferation and preventing apoptosis, while also targeting the Wnt/β-catenin pathway [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746]. In oesophageal squamous cell carcinoma, the circITCH is downregulated and increases ITCH expression to inhibit the Wnt/β-catenin pathway [Lee et al. DOI:10.1016/j.biopha.2018.12.052]. circITCH hsa_circ_0001141 (circITCH) was found to be lower in the hearts of cancer patients suffering from doxorubicin-induced cardiomyopathy compared to those with dilated cardiomyopathy, hypertrophic cardiomyopathy, and healthy donors, and its expression ameliorates doxorubicin-induced cardiomyocyte injury [Tian et al. DOI:10.3390/molecules26041155].