Basic Information

Symbol
circITCH
RNA Class
circRNA
Alias
Itchy E3 Ubiquitin Protein Ligase AIP4 HECT-Type E3 Ubiquitin Transferase Itchy Homolog E3 Ubiquitin-Protein Ligase Itchy Homolog NFE2-Associated Polypeptide 1 NAPP1 Itchy (Mouse Homolog) E3 Ubiquitin Protein Ligase Itchy E3 Ubiquitin Protein Ligase Homolog (Mouse) Itchy E3 Ubiquitin Protein Ligase Homolog Atrophin-1 Interacting Protein 4 Atrophin-1-Interacting Protein 4 EC 2.3.2.26 EC 6.3.2 ADMFD AIF4 Itch
Location (GRCh37)
20:32951062-33099197 UCSC Genome Browser
Location (GRCh38)
20:34363256-34511392
UCSC Genome Browser Search in Marker Scope
Host gene
ITCH
Host category
mRNA
Forensic tag(s)
Other applications
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_ITCH_0003800 Intron-Exon-Intron chr20:32980543-33037285 chr20:34392737-34449480 2408 nt 0.4444
hsa_ITCH_0003900 Intron-Exon-Intron chr20:32980543-33080402 chr20:34392737-34492597 250 nt 0.3960
hsa_ITCH_0004000 Intron-Exon-Intron chr20:32980543-33092208 chr20:34392737-34504403 250 nt 0.4080
hsa_ITCH_0004100 Intron-Exon chr20:32980543-33095713 chr20:34392737-34507908 250 nt 0.3920
hsa_ITCH_0004400 Intron-Exon-Intron chr20:32981576-32996598 chr20:34393770-34408792 254 nt 0.4291
hsa_ITCH_0004500 Intron-Exon-Intron chr20:32981576-33000445 chr20:34393770-34412639 379 nt 0.4037
hsa_ITCH_0004600 Intron-Exon-Intron chr20:32981576-33001685 chr20:34393770-34413879 517 nt 0.4043
hsa_ITCH_0004700 Intron-Exon-Intron chr20:32981576-33012331 chr20:34393770-34424525 410 nt 0.4805
hsa_ITCH_0005300 Intron-Exon-Intron chr20:32981597-32985127 chr20:34393791-34397321 91 nt 0.4505
hsa_ITCH_0005400 Exon-Exon chr20:32981597-32996598 chr20:34393791-34408792 142 nt 0.4085
Showing 101 to 110 of 255 entries
Forensic Context

A review consolidating research in humans and model organisms indicates that the circITCH functions as a tumor suppressor in glioma by sponging miR-214 to allow expression of ubiquitin-protein ligase E3, thereby suppressing proliferation and preventing apoptosis, while also targeting the Wnt/β-catenin pathway [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746]. In oesophageal squamous cell carcinoma, the circITCH is downregulated and increases ITCH expression to inhibit the Wnt/β-catenin pathway [Lee et al. DOI:10.1016/j.biopha.2018.12.052]. circITCH hsa_circ_0001141 (circITCH) was found to be lower in the hearts of cancer patients suffering from doxorubicin-induced cardiomyopathy compared to those with dilated cardiomyopathy, hypertrophic cardiomyopathy, and healthy donors, and its expression ameliorates doxorubicin-induced cardiomyocyte injury [Tian et al. DOI:10.3390/molecules26041155].