Basic Information

Symbol
circITCH
RNA Class
circRNA
Alias
Itchy E3 Ubiquitin Protein Ligase AIP4 HECT-Type E3 Ubiquitin Transferase Itchy Homolog E3 Ubiquitin-Protein Ligase Itchy Homolog NFE2-Associated Polypeptide 1 NAPP1 Itchy (Mouse Homolog) E3 Ubiquitin Protein Ligase Itchy E3 Ubiquitin Protein Ligase Homolog (Mouse) Itchy E3 Ubiquitin Protein Ligase Homolog Atrophin-1 Interacting Protein 4 Atrophin-1-Interacting Protein 4 EC 2.3.2.26 EC 6.3.2 ADMFD AIF4 Itch
Location (GRCh37)
20:32951062-33099197 UCSC Genome Browser
Location (GRCh38)
20:34363256-34511392
UCSC Genome Browser Search in Marker Scope
Host gene
ITCH
Host category
mRNA
Forensic tag(s)
Other applications
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_ITCH_0005000 Exon-Exon chr20:32981597-33000445 chr20:34393791-34412639 358 nt 0.3994
hsa_ITCH_0005100 Exon-Exon chr20:32981597-33005045 chr20:34393791-34417239 619 nt 0.4313
hsa_ITCH_0005600 Exon-Exon chr20:32981597-33028149 chr20:34393791-34440344 281 nt 0.4555
hsa_ITCH_0005700 Exon-Exon chr20:32981597-33037285 chr20:34393791-34449480 91 nt 0.4505
hsa_ITCH_0005200 Exon-Exon chr20:32981597-33045279 chr20:34393791-34457474 1439 nt 0.4496
hsa_ITCH_0005800 Exon-Exon chr20:32981597-33059320 chr20:34393791-34471515 163 nt 0.4294
hsa_ITCH_0004900 Exon-Exon chr20:32981597-33069011 chr20:34393791-34481206 2237 nt 0.4287
hsa_ITCH_0005900 Exon-Exon chr20:32981597-33080402 chr20:34393791-34492597 293 nt 0.4232
hsa_ITCH_0006000 Exon-Exon chr20:32981597-33095713 chr20:34393791-34507908 137 nt 0.4526
hsa_ITCH_0006100 Intron-Exon-Intron chr20:32985014-33001685 chr20:34397208-34413879 263 nt 0.3802
Showing 111 to 120 of 255 entries
Forensic Context

A review consolidating research in humans and model organisms indicates that the circITCH functions as a tumor suppressor in glioma by sponging miR-214 to allow expression of ubiquitin-protein ligase E3, thereby suppressing proliferation and preventing apoptosis, while also targeting the Wnt/β-catenin pathway [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746]. In oesophageal squamous cell carcinoma, the circITCH is downregulated and increases ITCH expression to inhibit the Wnt/β-catenin pathway [Lee et al. DOI:10.1016/j.biopha.2018.12.052]. circITCH hsa_circ_0001141 (circITCH) was found to be lower in the hearts of cancer patients suffering from doxorubicin-induced cardiomyopathy compared to those with dilated cardiomyopathy, hypertrophic cardiomyopathy, and healthy donors, and its expression ameliorates doxorubicin-induced cardiomyocyte injury [Tian et al. DOI:10.3390/molecules26041155].