Basic Information

Symbol
circITCH
RNA Class
circRNA
Alias
Itchy E3 Ubiquitin Protein Ligase AIP4 HECT-Type E3 Ubiquitin Transferase Itchy Homolog E3 Ubiquitin-Protein Ligase Itchy Homolog NFE2-Associated Polypeptide 1 NAPP1 Itchy (Mouse Homolog) E3 Ubiquitin Protein Ligase Itchy E3 Ubiquitin Protein Ligase Homolog (Mouse) Itchy E3 Ubiquitin Protein Ligase Homolog Atrophin-1 Interacting Protein 4 Atrophin-1-Interacting Protein 4 EC 2.3.2.26 EC 6.3.2 ADMFD AIF4 Itch
Location (GRCh37)
20:32951062-33099197 UCSC Genome Browser
Location (GRCh38)
20:34363256-34511392
UCSC Genome Browser Search in Marker Scope
Host gene
ITCH
Host category
mRNA
Forensic tag(s)
Other applications
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_ITCH_0006200 Intron-Exon-Intron chr20:32985014-33037285 chr20:34397208-34449480 70 nt 0.3857
hsa_ITCH_0006300 Intron-Intron chr20:32987583-32987800 chr20:34399777-34399994 218 nt 0.4908
hsa_ITCH_0006400 Intron-Exon-Intron chr20:32989157-32996598 chr20:34401351-34408792 250 nt 0.3080
hsa_ITCH_0006500 Intron-Intron chr20:32991516-32991700 chr20:34403710-34403894 185 nt 0.3514
hsa_ITCH_0007000 Exon-Exon chr20:32996457-33012331 chr20:34408651-34424525 188 nt 0.4202
hsa_ITCH_0006800 Exon-Exon chr20:32996457-33033266 chr20:34408651-34445461 1193 nt 0.4535
hsa_ITCH_0007100 Exon-Exon chr20:32996457-33037285 chr20:34408651-34449480 70 nt 0.3857
hsa_ITCH_0006900 Exon-Exon chr20:32996457-33050026 chr20:34408651-34462221 1477 nt 0.4462
hsa_ITCH_0007200 Exon-Exon chr20:32996457-33057925 chr20:34408651-34470120 70 nt 0.3857
hsa_ITCH_0007300 Exon-Exon chr20:32996457-33059320 chr20:34408651-34471515 339 nt 0.3864
Showing 121 to 130 of 255 entries
Forensic Context

A review consolidating research in humans and model organisms indicates that the circITCH functions as a tumor suppressor in glioma by sponging miR-214 to allow expression of ubiquitin-protein ligase E3, thereby suppressing proliferation and preventing apoptosis, while also targeting the Wnt/β-catenin pathway [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746]. In oesophageal squamous cell carcinoma, the circITCH is downregulated and increases ITCH expression to inhibit the Wnt/β-catenin pathway [Lee et al. DOI:10.1016/j.biopha.2018.12.052]. circITCH hsa_circ_0001141 (circITCH) was found to be lower in the hearts of cancer patients suffering from doxorubicin-induced cardiomyopathy compared to those with dilated cardiomyopathy, hypertrophic cardiomyopathy, and healthy donors, and its expression ameliorates doxorubicin-induced cardiomyocyte injury [Tian et al. DOI:10.3390/molecules26041155].