Basic Information

Symbol
circITCH
RNA Class
circRNA
Alias
Itchy E3 Ubiquitin Protein Ligase AIP4 HECT-Type E3 Ubiquitin Transferase Itchy Homolog E3 Ubiquitin-Protein Ligase Itchy Homolog NFE2-Associated Polypeptide 1 NAPP1 Itchy (Mouse Homolog) E3 Ubiquitin Protein Ligase Itchy E3 Ubiquitin Protein Ligase Homolog (Mouse) Itchy E3 Ubiquitin Protein Ligase Homolog Atrophin-1 Interacting Protein 4 Atrophin-1-Interacting Protein 4 EC 2.3.2.26 EC 6.3.2 ADMFD AIF4 Itch
Location (GRCh37)
20:32951062-33099197 UCSC Genome Browser
Location (GRCh38)
20:34363256-34511392
UCSC Genome Browser Search in Marker Scope
Host gene
ITCH
Host category
mRNA
Forensic tag(s)
Other applications
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_ITCH_0006700 Exon-Exon chr20:32996457-33069011 chr20:34408651-34481206 2146 nt 0.4278
hsa_ITCH_0007400 Exon-Exon chr20:32996457-33095713 chr20:34408651-34507908 142 nt 0.4085
hsa_ITCH_0007500 Exon-Intron chr20:32996519-32996790 chr20:34408713-34408984 272 nt 0.3309
hsa_ITCH_0007600 Intron-Exon-Intron chr20:32997297-33003249 chr20:34409491-34415443 250 nt 0.3120
hsa_ITCH_0008000 Exon-Exon chr20:33000321-33012331 chr20:34412515-34424525 171 nt 0.3801
hsa_ITCH_0008100 Exon-Exon chr20:33000321-33037285 chr20:34412515-34449480 125 nt 0.3520
hsa_ITCH_0008200 Exon-Exon chr20:33000321-33045279 chr20:34412515-34457474 91 nt 0.4396
hsa_ITCH_0008300 Exon-Exon chr20:33000321-33050026 chr20:34412515-34462221 125 nt 0.3520
hsa_ITCH_0008400 Exon-Exon chr20:33000321-33057925 chr20:34412515-34470120 125 nt 0.3520
hsa_ITCH_0007900 Exon-Exon chr20:33000321-33059320 chr20:34412515-34471515 1480 nt 0.4486
Showing 131 to 140 of 255 entries
Forensic Context

A review consolidating research in humans and model organisms indicates that the circITCH functions as a tumor suppressor in glioma by sponging miR-214 to allow expression of ubiquitin-protein ligase E3, thereby suppressing proliferation and preventing apoptosis, while also targeting the Wnt/β-catenin pathway [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746]. In oesophageal squamous cell carcinoma, the circITCH is downregulated and increases ITCH expression to inhibit the Wnt/β-catenin pathway [Lee et al. DOI:10.1016/j.biopha.2018.12.052]. circITCH hsa_circ_0001141 (circITCH) was found to be lower in the hearts of cancer patients suffering from doxorubicin-induced cardiomyopathy compared to those with dilated cardiomyopathy, hypertrophic cardiomyopathy, and healthy donors, and its expression ameliorates doxorubicin-induced cardiomyocyte injury [Tian et al. DOI:10.3390/molecules26041155].