Basic Information

Symbol
circITCH
RNA Class
circRNA
Alias
Itchy E3 Ubiquitin Protein Ligase AIP4 HECT-Type E3 Ubiquitin Transferase Itchy Homolog E3 Ubiquitin-Protein Ligase Itchy Homolog NFE2-Associated Polypeptide 1 NAPP1 Itchy (Mouse Homolog) E3 Ubiquitin Protein Ligase Itchy E3 Ubiquitin Protein Ligase Homolog (Mouse) Itchy E3 Ubiquitin Protein Ligase Homolog Atrophin-1 Interacting Protein 4 Atrophin-1-Interacting Protein 4 EC 2.3.2.26 EC 6.3.2 ADMFD AIF4 Itch
Location (GRCh37)
20:32951062-33099197 UCSC Genome Browser
Location (GRCh38)
20:34363256-34511392
UCSC Genome Browser Search in Marker Scope
Host gene
ITCH
Host category
mRNA
Forensic tag(s)
Other applications
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_ITCH_0008500 Exon-Exon chr20:33000321-33069011 chr20:34412515-34481206 435 nt 0.3609
hsa_ITCH_0008600 Exon-Exon chr20:33000321-33095713 chr20:34412515-34507908 46 nt 0.4565
hsa_ITCH_0008700 Intron-Exon-Intron chr20:33000860-33059320 chr20:34413054-34471515 2043 nt 0.4048
hsa_ITCH_0008800 Intron-Exon chr20:33000860-33095713 chr20:34413054-34507908 250 nt 0.3520
hsa_ITCH_0008900 Intron-Exon-Intron chr20:33001070-33001685 chr20:34413264-34413879 616 nt 0.2938
hsa_ITCH_0009700 Intron-Exon-Intron chr20:33001548-33001924 chr20:34413742-34414118 377 nt 0.4058
hsa_ITCH_0009800 Intron-Exon-Intron chr20:33001548-33003005 chr20:34413742-34415199 1458 nt 0.3855
hsa_ITCH_0009900 Exon-Exon chr20:33001548-33005045 chr20:34413742-34417239 261 nt 0.4751
hsa_ITCH_0009600 Intron-Exon-Intron chr20:33001548-33009632 chr20:34413742-34421826 250 nt 0.4000
hsa_ITCH_0010100 Intron-Exon-Intron chr20:33001548-33018143 chr20:34413742-34430337 334 nt 0.4251
Showing 141 to 150 of 255 entries
Forensic Context

A review consolidating research in humans and model organisms indicates that the circITCH functions as a tumor suppressor in glioma by sponging miR-214 to allow expression of ubiquitin-protein ligase E3, thereby suppressing proliferation and preventing apoptosis, while also targeting the Wnt/β-catenin pathway [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746]. In oesophageal squamous cell carcinoma, the circITCH is downregulated and increases ITCH expression to inhibit the Wnt/β-catenin pathway [Lee et al. DOI:10.1016/j.biopha.2018.12.052]. circITCH hsa_circ_0001141 (circITCH) was found to be lower in the hearts of cancer patients suffering from doxorubicin-induced cardiomyopathy compared to those with dilated cardiomyopathy, hypertrophic cardiomyopathy, and healthy donors, and its expression ameliorates doxorubicin-induced cardiomyocyte injury [Tian et al. DOI:10.3390/molecules26041155].