Basic Information

Symbol
circITCH
RNA Class
circRNA
Alias
Itchy E3 Ubiquitin Protein Ligase AIP4 HECT-Type E3 Ubiquitin Transferase Itchy Homolog E3 Ubiquitin-Protein Ligase Itchy Homolog NFE2-Associated Polypeptide 1 NAPP1 Itchy (Mouse Homolog) E3 Ubiquitin Protein Ligase Itchy E3 Ubiquitin Protein Ligase Homolog (Mouse) Itchy E3 Ubiquitin Protein Ligase Homolog Atrophin-1 Interacting Protein 4 Atrophin-1-Interacting Protein 4 EC 2.3.2.26 EC 6.3.2 ADMFD AIF4 Itch
Location (GRCh37)
20:32951062-33099197 UCSC Genome Browser
Location (GRCh38)
20:34363256-34511392
UCSC Genome Browser Search in Marker Scope
Host gene
ITCH
Host category
mRNA
Forensic tag(s)
Other applications
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_ITCH_0011100 Exon-Exon chr20:33001548-33095713 chr20:34413742-34507908 340 nt 0.4088
hsa_ITCH_0011200 Exon-Exon chr20:33001574-33095713 chr20:34413768-34507908 287 nt 0.4146
hsa_chr20_0092700 Intergenic-Intergenic chr20:33001940-33007464 chr20:34414134-34419658 250 nt 0.2880
hsa_chr20_0092800 Intergenic-Intergenic chr20:33001940-33027077 chr20:34414134-34439272 250 nt 0.1840
hsa_ITCH_0011500 Intron-Intron chr20:33003299-33004900 chr20:34415493-34417094 1602 nt 0.4313
hsa_ITCH_0011300 Intron-Exon-Intron chr20:33003299-33005823 chr20:34415493-34418017 2525 nt 0.4428
hsa_ITCH_0011400 Intron-Exon-Intron chr20:33003299-33007338 chr20:34415493-34419532 250 nt 0.3400
hsa_chr20_0092900 Intergenic-Intergenic chr20:33003685-33010849 chr20:34415879-34423043 250 nt 0.3920
hsa_ITCH_0011600 Intron-Exon-Intron chr20:33003978-33005138 chr20:34416172-34417332 1161 nt 0.4255
hsa_ITCH_0011700 Intron-Exon-Intron chr20:33004396-33005045 chr20:34416590-34417239 650 nt 0.4092
Showing 151 to 160 of 255 entries
Forensic Context

A review consolidating research in humans and model organisms indicates that the circITCH functions as a tumor suppressor in glioma by sponging miR-214 to allow expression of ubiquitin-protein ligase E3, thereby suppressing proliferation and preventing apoptosis, while also targeting the Wnt/β-catenin pathway [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746]. In oesophageal squamous cell carcinoma, the circITCH is downregulated and increases ITCH expression to inhibit the Wnt/β-catenin pathway [Lee et al. DOI:10.1016/j.biopha.2018.12.052]. circITCH hsa_circ_0001141 (circITCH) was found to be lower in the hearts of cancer patients suffering from doxorubicin-induced cardiomyopathy compared to those with dilated cardiomyopathy, hypertrophic cardiomyopathy, and healthy donors, and its expression ameliorates doxorubicin-induced cardiomyocyte injury [Tian et al. DOI:10.3390/molecules26041155].