Basic Information

Symbol
circITCH
RNA Class
circRNA
Alias
Itchy E3 Ubiquitin Protein Ligase AIP4 HECT-Type E3 Ubiquitin Transferase Itchy Homolog E3 Ubiquitin-Protein Ligase Itchy Homolog NFE2-Associated Polypeptide 1 NAPP1 Itchy (Mouse Homolog) E3 Ubiquitin Protein Ligase Itchy E3 Ubiquitin Protein Ligase Homolog (Mouse) Itchy E3 Ubiquitin Protein Ligase Homolog Atrophin-1 Interacting Protein 4 Atrophin-1-Interacting Protein 4 EC 2.3.2.26 EC 6.3.2 ADMFD AIF4 Itch
Location (GRCh37)
20:32951062-33099197 UCSC Genome Browser
Location (GRCh38)
20:34363256-34511392
UCSC Genome Browser Search in Marker Scope
Host gene
ITCH
Host category
mRNA
Forensic tag(s)
Other applications
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_ITCH_0011800 Intron-Exon-Intron chr20:33004923-33018143 chr20:34417117-34430337 250 nt 0.4080
hsa_ITCH_0011900 Exon-Exon chr20:33004923-33028149 chr20:34417117-34440344 190 nt 0.4579
hsa_ITCH_0012000 Intron-Exon-Intron chr20:33008936-33050026 chr20:34421130-34462221 250 nt 0.3920
hsa_ITCH_0012300 Intron-Exon-Intron chr20:33009489-33037285 chr20:34421683-34449480 144 nt 0.4792
hsa_ITCH_0012400 Intron-Exon-Intron chr20:33009489-33050026 chr20:34421683-34462221 319 nt 0.4483
hsa_ITCH_0012100 Intron-Exon-Intron chr20:33009489-33059320 chr20:34421683-34471515 250 nt 0.3560
hsa_ITCH_0012500 Intron-Exon-Intron chr20:33009489-33069011 chr20:34421683-34481206 134 nt 0.3657
hsa_ITCH_0012200 Intron-Exon-Intron chr20:33009489-33080402 chr20:34421683-34492597 250 nt 0.3480
hsa_ITCH_0012600 Intron-Exon chr20:33009513-33095713 chr20:34421707-34507908 250 nt 0.3640
hsa_ITCH_0012800 Intron-Exon-Intron chr20:33009538-33037285 chr20:34421732-34449480 70 nt 0.3857
Showing 161 to 170 of 255 entries
Forensic Context

A review consolidating research in humans and model organisms indicates that the circITCH functions as a tumor suppressor in glioma by sponging miR-214 to allow expression of ubiquitin-protein ligase E3, thereby suppressing proliferation and preventing apoptosis, while also targeting the Wnt/β-catenin pathway [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746]. In oesophageal squamous cell carcinoma, the circITCH is downregulated and increases ITCH expression to inhibit the Wnt/β-catenin pathway [Lee et al. DOI:10.1016/j.biopha.2018.12.052]. circITCH hsa_circ_0001141 (circITCH) was found to be lower in the hearts of cancer patients suffering from doxorubicin-induced cardiomyopathy compared to those with dilated cardiomyopathy, hypertrophic cardiomyopathy, and healthy donors, and its expression ameliorates doxorubicin-induced cardiomyocyte injury [Tian et al. DOI:10.3390/molecules26041155].