Basic Information

Symbol
circITCH
RNA Class
circRNA
Alias
Itchy E3 Ubiquitin Protein Ligase AIP4 HECT-Type E3 Ubiquitin Transferase Itchy Homolog E3 Ubiquitin-Protein Ligase Itchy Homolog NFE2-Associated Polypeptide 1 NAPP1 Itchy (Mouse Homolog) E3 Ubiquitin Protein Ligase Itchy E3 Ubiquitin Protein Ligase Homolog (Mouse) Itchy E3 Ubiquitin Protein Ligase Homolog Atrophin-1 Interacting Protein 4 Atrophin-1-Interacting Protein 4 EC 2.3.2.26 EC 6.3.2 ADMFD AIF4 Itch
Location (GRCh37)
20:32951062-33099197 UCSC Genome Browser
Location (GRCh38)
20:34363256-34511392
UCSC Genome Browser Search in Marker Scope
Host gene
ITCH
Host category
mRNA
Forensic tag(s)
Other applications
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_ITCH_0012700 Intron-Exon-Intron chr20:33009538-33050026 chr20:34421732-34462221 250 nt 0.4000
hsa_ITCH_0012900 Intron-Exon-Intron chr20:33009538-33069011 chr20:34421732-34481206 141 nt 0.3333
hsa_ITCH_0013000 Intron-Exon-Intron chr20:33011850-33080402 chr20:34424044-34492597 141 nt 0.4326
hsa_ITCH_0013400 Intron-Exon-Intron chr20:33012286-33014187 chr20:34424480-34426381 1902 nt 0.4343
hsa_ITCH_0013700 Intron-Exon-Intron chr20:33012286-33018143 chr20:34424480-34430337 196 nt 0.4388
hsa_ITCH_0014100 Intron-Exon-Intron chr20:33012286-33050774 chr20:34424480-34462969 142 nt 0.4789
hsa_ITCH_0014700 Exon-Exon chr20:33012286-33095713 chr20:34424480-34507908 260 nt 0.4192
hsa_ITCH_0014800 Intron-Intron chr20:33013996-33018143 chr20:34426190-34430337 150 nt 0.4333
hsa_chr20_0093000 Intergenic-Intergenic chr20:33015218-33015592 chr20:34427412-34427786 375 nt 0.3733
hsa_ITCH_0014900 Intron-Intron chr20:33016956-33019632 chr20:34429150-34431826 2677 nt 0.3990
Showing 171 to 180 of 255 entries
Forensic Context

A review consolidating research in humans and model organisms indicates that the circITCH functions as a tumor suppressor in glioma by sponging miR-214 to allow expression of ubiquitin-protein ligase E3, thereby suppressing proliferation and preventing apoptosis, while also targeting the Wnt/β-catenin pathway [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746]. In oesophageal squamous cell carcinoma, the circITCH is downregulated and increases ITCH expression to inhibit the Wnt/β-catenin pathway [Lee et al. DOI:10.1016/j.biopha.2018.12.052]. circITCH hsa_circ_0001141 (circITCH) was found to be lower in the hearts of cancer patients suffering from doxorubicin-induced cardiomyopathy compared to those with dilated cardiomyopathy, hypertrophic cardiomyopathy, and healthy donors, and its expression ameliorates doxorubicin-induced cardiomyocyte injury [Tian et al. DOI:10.3390/molecules26041155].