Basic Information

Symbol
circITCH
RNA Class
circRNA
Alias
Itchy E3 Ubiquitin Protein Ligase AIP4 HECT-Type E3 Ubiquitin Transferase Itchy Homolog E3 Ubiquitin-Protein Ligase Itchy Homolog NFE2-Associated Polypeptide 1 NAPP1 Itchy (Mouse Homolog) E3 Ubiquitin Protein Ligase Itchy E3 Ubiquitin Protein Ligase Homolog (Mouse) Itchy E3 Ubiquitin Protein Ligase Homolog Atrophin-1 Interacting Protein 4 Atrophin-1-Interacting Protein 4 EC 2.3.2.26 EC 6.3.2 ADMFD AIF4 Itch
Location (GRCh37)
20:32951062-33099197 UCSC Genome Browser
Location (GRCh38)
20:34363256-34511392
UCSC Genome Browser Search in Marker Scope
Host gene
ITCH
Host category
mRNA
Forensic tag(s)
Other applications
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_chr20_0093100 Intergenic-Intergenic chr20:33017035-33018934 chr20:34429229-34431128 1900 nt 0.3716
hsa_ITCH_0015100 Intron-Exon-Intron chr20:33017994-33030108 chr20:34430188-34442303 102 nt 0.4902
hsa_ITCH_0015200 Intron-Exon-Intron chr20:33017994-33033266 chr20:34430188-34445461 308 nt 0.4610
hsa_ITCH_0015300 Intron-Exon-Intron chr20:33017994-33037285 chr20:34430188-34449480 220 nt 0.4182
hsa_ITCH_0015400 Intron-Exon-Intron chr20:33017994-33045279 chr20:34430188-34457474 308 nt 0.4610
hsa_ITCH_0015500 Intron-Exon-Intron chr20:33017994-33050026 chr20:34430188-34462221 70 nt 0.3857
hsa_ITCH_0015600 Intron-Exon-Intron chr20:33017994-33059320 chr20:34430188-34471515 380 nt 0.4500
hsa_ITCH_0015700 Intron-Exon-Intron chr20:33017994-33069011 chr20:34430188-34481206 147 nt 0.3401
hsa_ITCH_0015800 Intron-Exon-Intron chr20:33017994-33080402 chr20:34430188-34492597 437 nt 0.4371
hsa_ITCH_0015000 Intron-Exon chr20:33017994-33095713 chr20:34430188-34507908 250 nt 0.3360
Showing 181 to 190 of 255 entries
Forensic Context

A review consolidating research in humans and model organisms indicates that the circITCH functions as a tumor suppressor in glioma by sponging miR-214 to allow expression of ubiquitin-protein ligase E3, thereby suppressing proliferation and preventing apoptosis, while also targeting the Wnt/β-catenin pathway [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746]. In oesophageal squamous cell carcinoma, the circITCH is downregulated and increases ITCH expression to inhibit the Wnt/β-catenin pathway [Lee et al. DOI:10.1016/j.biopha.2018.12.052]. circITCH hsa_circ_0001141 (circITCH) was found to be lower in the hearts of cancer patients suffering from doxorubicin-induced cardiomyopathy compared to those with dilated cardiomyopathy, hypertrophic cardiomyopathy, and healthy donors, and its expression ameliorates doxorubicin-induced cardiomyocyte injury [Tian et al. DOI:10.3390/molecules26041155].