Basic Information

Symbol
circITCH
RNA Class
circRNA
Alias
Itchy E3 Ubiquitin Protein Ligase AIP4 HECT-Type E3 Ubiquitin Transferase Itchy Homolog E3 Ubiquitin-Protein Ligase Itchy Homolog NFE2-Associated Polypeptide 1 NAPP1 Itchy (Mouse Homolog) E3 Ubiquitin Protein Ligase Itchy E3 Ubiquitin Protein Ligase Homolog (Mouse) Itchy E3 Ubiquitin Protein Ligase Homolog Atrophin-1 Interacting Protein 4 Atrophin-1-Interacting Protein 4 EC 2.3.2.26 EC 6.3.2 ADMFD AIF4 Itch
Location (GRCh37)
20:32951062-33099197 UCSC Genome Browser
Location (GRCh38)
20:34363256-34511392
UCSC Genome Browser Search in Marker Scope
Host gene
ITCH
Host category
mRNA
Forensic tag(s)
Other applications
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_ITCH_0006600 Exon-Exon chr20:32996457-33001685 chr20:34408651-34413879 405 nt 0.3901
hsa_ITCH_0007700 Exon-Exon chr20:33000321-33001685 chr20:34412515-34413879 263 nt 0.3802
hsa_ITCH_0007800 Exon-Exon chr20:33000321-33030108 chr20:34412515-34442303 876 nt 0.4566
hsa_ITCH_0009000 Exon-Exon chr20:33001548-33001685 chr20:34413742-34413879 138 nt 0.4058
hsa_ITCH_0010000 Exon-Exon chr20:33001548-33012331 chr20:34413742-34424525 184 nt 0.4185
hsa_ITCH_0010300 Exon-Exon chr20:33001548-33028149 chr20:34413742-34440344 532 nt 0.4530
hsa_ITCH_0009100 Exon-Exon chr20:33001548-33030108 chr20:34413742-34442303 751 nt 0.4740
hsa_ITCH_0010500 Exon-Exon chr20:33001548-33037285 chr20:34413742-34449480 873 nt 0.4559
hsa_ITCH_0009200 Exon-Exon chr20:33001548-33045279 chr20:34413742-34457474 1081 nt 0.4662
hsa_ITCH_0009300 Exon-Exon chr20:33001548-33050026 chr20:34413742-34462221 1210 nt 0.4603
Showing 11 to 20 of 255 entries
Forensic Context

A review consolidating research in humans and model organisms indicates that the circITCH functions as a tumor suppressor in glioma by sponging miR-214 to allow expression of ubiquitin-protein ligase E3, thereby suppressing proliferation and preventing apoptosis, while also targeting the Wnt/β-catenin pathway [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746]. In oesophageal squamous cell carcinoma, the circITCH is downregulated and increases ITCH expression to inhibit the Wnt/β-catenin pathway [Lee et al. DOI:10.1016/j.biopha.2018.12.052]. circITCH hsa_circ_0001141 (circITCH) was found to be lower in the hearts of cancer patients suffering from doxorubicin-induced cardiomyopathy compared to those with dilated cardiomyopathy, hypertrophic cardiomyopathy, and healthy donors, and its expression ameliorates doxorubicin-induced cardiomyocyte injury [Tian et al. DOI:10.3390/molecules26041155].