Basic Information

Symbol
circITCH
RNA Class
circRNA
Alias
Itchy E3 Ubiquitin Protein Ligase AIP4 HECT-Type E3 Ubiquitin Transferase Itchy Homolog E3 Ubiquitin-Protein Ligase Itchy Homolog NFE2-Associated Polypeptide 1 NAPP1 Itchy (Mouse Homolog) E3 Ubiquitin Protein Ligase Itchy E3 Ubiquitin Protein Ligase Homolog (Mouse) Itchy E3 Ubiquitin Protein Ligase Homolog Atrophin-1 Interacting Protein 4 Atrophin-1-Interacting Protein 4 EC 2.3.2.26 EC 6.3.2 ADMFD AIF4 Itch
Location (GRCh37)
20:32951062-33099197 UCSC Genome Browser
Location (GRCh38)
20:34363256-34511392
UCSC Genome Browser Search in Marker Scope
Host gene
ITCH
Host category
mRNA
Forensic tag(s)
Other applications
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_chr20_0093200 Intergenic-Intergenic chr20:33018479-33020877 chr20:34430673-34433071 2399 nt 0.4135
hsa_chr20_0093300 Intergenic-Intergenic chr20:33018573-33018934 chr20:34430767-34431128 362 nt 0.4088
hsa_ITCH_0015900 Intron-Intron chr20:33018746-33019446 chr20:34430940-34431640 701 nt 0.4522
hsa_ITCH_0017200 Exon-Exon chr20:33026279-33095713 chr20:34438474-34507908 158 nt 0.4873
hsa_ITCH_0017300 Exon-Exon chr20:33026311-33027995 chr20:34438506-34440190 162 nt 0.4815
hsa_chr20_0093400 Intergenic-Intergenic chr20:33026410-33028016 chr20:34438605-34440211 84 nt 0.5357
hsa_chr20_0093500 Intergenic-Intergenic chr20:33026419-33028145 chr20:34438614-34440340 204 nt 0.4706
hsa_ITCH_0018700 Intron-Intron chr20:33028985-33029485 chr20:34441180-34441680 501 nt 0.4132
hsa_ITCH_0019700 Intron-Exon-Intron chr20:33032296-33068097 chr20:34444491-34480292 2152 nt 0.4270
hsa_ITCH_0020400 Intron-Intron chr20:33033315-33034657 chr20:34445510-34446852 1343 nt 0.3537
Showing 191 to 200 of 255 entries
Forensic Context

A review consolidating research in humans and model organisms indicates that the circITCH functions as a tumor suppressor in glioma by sponging miR-214 to allow expression of ubiquitin-protein ligase E3, thereby suppressing proliferation and preventing apoptosis, while also targeting the Wnt/β-catenin pathway [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746]. In oesophageal squamous cell carcinoma, the circITCH is downregulated and increases ITCH expression to inhibit the Wnt/β-catenin pathway [Lee et al. DOI:10.1016/j.biopha.2018.12.052]. circITCH hsa_circ_0001141 (circITCH) was found to be lower in the hearts of cancer patients suffering from doxorubicin-induced cardiomyopathy compared to those with dilated cardiomyopathy, hypertrophic cardiomyopathy, and healthy donors, and its expression ameliorates doxorubicin-induced cardiomyocyte injury [Tian et al. DOI:10.3390/molecules26041155].