Basic Information

Symbol
circITCH
RNA Class
circRNA
Alias
Itchy E3 Ubiquitin Protein Ligase AIP4 HECT-Type E3 Ubiquitin Transferase Itchy Homolog E3 Ubiquitin-Protein Ligase Itchy Homolog NFE2-Associated Polypeptide 1 NAPP1 Itchy (Mouse Homolog) E3 Ubiquitin Protein Ligase Itchy E3 Ubiquitin Protein Ligase Homolog (Mouse) Itchy E3 Ubiquitin Protein Ligase Homolog Atrophin-1 Interacting Protein 4 Atrophin-1-Interacting Protein 4 EC 2.3.2.26 EC 6.3.2 ADMFD AIF4 Itch
Location (GRCh37)
20:32951062-33099197 UCSC Genome Browser
Location (GRCh38)
20:34363256-34511392
UCSC Genome Browser Search in Marker Scope
Host gene
ITCH
Host category
mRNA
Forensic tag(s)
Other applications
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_ITCH_0020800 Exon-Exon chr20:33037216-33095713 chr20:34449411-34507908 353 nt 0.4051
hsa_ITCH_0020900 Intron-Exon-Intron chr20:33037526-33045279 chr20:34449721-34457474 250 nt 0.3400
hsa_ITCH_0021000 Intron-Exon-Intron chr20:33037526-33050026 chr20:34449721-34462221 201 nt 0.3632
hsa_ITCH_0021100 Intron-Exon-Intron chr20:33037526-33069011 chr20:34449721-34481206 147 nt 0.3197
hsa_ITCH_0021200 Intron-Exon-Intron chr20:33037526-33092208 chr20:34449721-34504403 146 nt 0.4452
hsa_ITCH_0021300 Intron-Exon-Intron chr20:33041087-33069011 chr20:34453282-34481206 250 nt 0.3200
hsa_ITCH_0021400 Intron-Exon-Intron chr20:33043465-33045279 chr20:34455660-34457474 165 nt 0.5394
hsa_ITCH_0022200 Intron-Exon-Intron chr20:33045195-33050774 chr20:34457390-34462969 79 nt 0.2911
hsa_ITCH_0022000 Intron-Exon-Intron chr20:33045195-33054994 chr20:34457390-34467189 250 nt 0.2720
hsa_ITCH_0022700 Intron-Intron chr20:33045738-33048990 chr20:34457933-34461185 250 nt 0.2600
Showing 201 to 210 of 255 entries
Forensic Context

A review consolidating research in humans and model organisms indicates that the circITCH functions as a tumor suppressor in glioma by sponging miR-214 to allow expression of ubiquitin-protein ligase E3, thereby suppressing proliferation and preventing apoptosis, while also targeting the Wnt/β-catenin pathway [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746]. In oesophageal squamous cell carcinoma, the circITCH is downregulated and increases ITCH expression to inhibit the Wnt/β-catenin pathway [Lee et al. DOI:10.1016/j.biopha.2018.12.052]. circITCH hsa_circ_0001141 (circITCH) was found to be lower in the hearts of cancer patients suffering from doxorubicin-induced cardiomyopathy compared to those with dilated cardiomyopathy, hypertrophic cardiomyopathy, and healthy donors, and its expression ameliorates doxorubicin-induced cardiomyocyte injury [Tian et al. DOI:10.3390/molecules26041155].