Basic Information

Symbol
circITCH
RNA Class
circRNA
Alias
Itchy E3 Ubiquitin Protein Ligase AIP4 HECT-Type E3 Ubiquitin Transferase Itchy Homolog E3 Ubiquitin-Protein Ligase Itchy Homolog NFE2-Associated Polypeptide 1 NAPP1 Itchy (Mouse Homolog) E3 Ubiquitin Protein Ligase Itchy E3 Ubiquitin Protein Ligase Homolog (Mouse) Itchy E3 Ubiquitin Protein Ligase Homolog Atrophin-1 Interacting Protein 4 Atrophin-1-Interacting Protein 4 EC 2.3.2.26 EC 6.3.2 ADMFD AIF4 Itch
Location (GRCh37)
20:32951062-33099197 UCSC Genome Browser
Location (GRCh38)
20:34363256-34511392
UCSC Genome Browser Search in Marker Scope
Host gene
ITCH
Host category
mRNA
Forensic tag(s)
Other applications
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_ITCH_0022800 Intron-Intron chr20:33048020-33048411 chr20:34460215-34460606 392 nt 0.4413
hsa_ITCH_0023200 Intron-Exon-Intron chr20:33049898-33050774 chr20:34462093-34462969 208 nt 0.3654
hsa_ITCH_0023600 Exon-Exon chr20:33049898-33095713 chr20:34462093-34507908 214 nt 0.4112
hsa_ITCH_0023700 Exon-Exon chr20:33049985-33065640 chr20:34462180-34477835 251 nt 0.4462
hsa_ITCH_0023800 Intron-Exon-Intron chr20:33054938-33077731 chr20:34467133-34489926 234 nt 0.3889
hsa_ITCH_0023900 Intron-Exon-Intron chr20:33054938-33080402 chr20:34467133-34492597 103 nt 0.3883
hsa_ITCH_0024400 Intron-Exon-Intron chr20:33057853-33072400 chr20:34470048-34484595 250 nt 0.3280
hsa_ITCH_0024800 Exon-Exon chr20:33057853-33095713 chr20:34470048-34507908 360 nt 0.4250
hsa_ITCH_0024900 Exon-Exon chr20:33057855-33069011 chr20:34470050-34481206 147 nt 0.3333
hsa_ITCH_0025000 Exon-Exon chr20:33057855-33080402 chr20:34470050-34492597 240 nt 0.4208
Showing 211 to 220 of 255 entries
Forensic Context

A review consolidating research in humans and model organisms indicates that the circITCH functions as a tumor suppressor in glioma by sponging miR-214 to allow expression of ubiquitin-protein ligase E3, thereby suppressing proliferation and preventing apoptosis, while also targeting the Wnt/β-catenin pathway [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746]. In oesophageal squamous cell carcinoma, the circITCH is downregulated and increases ITCH expression to inhibit the Wnt/β-catenin pathway [Lee et al. DOI:10.1016/j.biopha.2018.12.052]. circITCH hsa_circ_0001141 (circITCH) was found to be lower in the hearts of cancer patients suffering from doxorubicin-induced cardiomyopathy compared to those with dilated cardiomyopathy, hypertrophic cardiomyopathy, and healthy donors, and its expression ameliorates doxorubicin-induced cardiomyocyte injury [Tian et al. DOI:10.3390/molecules26041155].