Basic Information

Symbol
circITCH
RNA Class
circRNA
Alias
Itchy E3 Ubiquitin Protein Ligase AIP4 HECT-Type E3 Ubiquitin Transferase Itchy Homolog E3 Ubiquitin-Protein Ligase Itchy Homolog NFE2-Associated Polypeptide 1 NAPP1 Itchy (Mouse Homolog) E3 Ubiquitin Protein Ligase Itchy E3 Ubiquitin Protein Ligase Homolog (Mouse) Itchy E3 Ubiquitin Protein Ligase Homolog Atrophin-1 Interacting Protein 4 Atrophin-1-Interacting Protein 4 EC 2.3.2.26 EC 6.3.2 ADMFD AIF4 Itch
Location (GRCh37)
20:32951062-33099197 UCSC Genome Browser
Location (GRCh38)
20:34363256-34511392
UCSC Genome Browser Search in Marker Scope
Host gene
ITCH
Host category
mRNA
Forensic tag(s)
Other applications
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_ITCH_0025100 Exon-Exon chr20:33057899-33065640 chr20:34470094-34477835 163 nt 0.4356
hsa_ITCH_0025300 Intron-Exon-Intron chr20:33058316-33067594 chr20:34470511-34479789 160 nt 0.3813
hsa_ITCH_0025400 Intron-Exon-Intron chr20:33058316-33069011 chr20:34470511-34481206 523 nt 0.3595
hsa_ITCH_0025500 Intron-Exon-Intron chr20:33058316-33080402 chr20:34470511-34492597 107 nt 0.3832
hsa_ITCH_0025200 Intron-Exon-Intron chr20:33058316-33092208 chr20:34470511-34504403 1925 nt 0.3725
hsa_ITCH_0025700 Intron-Exon-Intron chr20:33058319-33069011 chr20:34470514-34481206 353 nt 0.3966
hsa_ITCH_0025600 Intron-Exon-Intron chr20:33058319-33092208 chr20:34470514-34504403 1922 nt 0.3725
hsa_ITCH_0025800 Intron-Exon-Intron chr20:33059203-33067594 chr20:34471398-34479789 207 nt 0.3961
hsa_ITCH_0025900 Intron-Exon-Intron chr20:33059203-33069011 chr20:34471398-34481206 488 nt 0.3607
hsa_ITCH_0026000 Intron-Exon-Intron chr20:33059203-33077731 chr20:34471398-34489926 105 nt 0.4190
Showing 221 to 230 of 255 entries
Forensic Context

A review consolidating research in humans and model organisms indicates that the circITCH functions as a tumor suppressor in glioma by sponging miR-214 to allow expression of ubiquitin-protein ligase E3, thereby suppressing proliferation and preventing apoptosis, while also targeting the Wnt/β-catenin pathway [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746]. In oesophageal squamous cell carcinoma, the circITCH is downregulated and increases ITCH expression to inhibit the Wnt/β-catenin pathway [Lee et al. DOI:10.1016/j.biopha.2018.12.052]. circITCH hsa_circ_0001141 (circITCH) was found to be lower in the hearts of cancer patients suffering from doxorubicin-induced cardiomyopathy compared to those with dilated cardiomyopathy, hypertrophic cardiomyopathy, and healthy donors, and its expression ameliorates doxorubicin-induced cardiomyocyte injury [Tian et al. DOI:10.3390/molecules26041155].