Basic Information

Symbol
circITCH
RNA Class
circRNA
Alias
Itchy E3 Ubiquitin Protein Ligase AIP4 HECT-Type E3 Ubiquitin Transferase Itchy Homolog E3 Ubiquitin-Protein Ligase Itchy Homolog NFE2-Associated Polypeptide 1 NAPP1 Itchy (Mouse Homolog) E3 Ubiquitin Protein Ligase Itchy E3 Ubiquitin Protein Ligase Homolog (Mouse) Itchy E3 Ubiquitin Protein Ligase Homolog Atrophin-1 Interacting Protein 4 Atrophin-1-Interacting Protein 4 EC 2.3.2.26 EC 6.3.2 ADMFD AIF4 Itch
Location (GRCh37)
20:32951062-33099197 UCSC Genome Browser
Location (GRCh38)
20:34363256-34511392
UCSC Genome Browser Search in Marker Scope
Host gene
ITCH
Host category
mRNA
Forensic tag(s)
Other applications
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_ITCH_0026100 Intron-Exon-Intron chr20:33059203-33080402 chr20:34471398-34492597 215 nt 0.3814
hsa_ITCH_0026900 Intron-Exon-Intron chr20:33065222-33073946 chr20:34477417-34486141 444 nt 0.3739
hsa_ITCH_0027700 Exon-Exon chr20:33065577-33095713 chr20:34477772-34507908 376 nt 0.4202
hsa_ITCH_0027900 Intron-Intron chr20:33065666-33066105 chr20:34477861-34478300 440 nt 0.3523
hsa_ITCH_0028000 Intron-Intron chr20:33066013-33066288 chr20:34478208-34478483 276 nt 0.3478
hsa_ITCH_0028500 Exon-Exon chr20:33067435-33095713 chr20:34479630-34507908 214 nt 0.4112
hsa_ITCH_0028600 Exon-Exon chr20:33067500-33068932 chr20:34479695-34481127 291 nt 0.3677
hsa_ITCH_0028700 Exon-Exon chr20:33067500-33069011 chr20:34479695-34481206 236 nt 0.3559
hsa_ITCH_0028800 Exon-Exon chr20:33067500-33092208 chr20:34479695-34504403 168 nt 0.4048
hsa_ITCH_0028900 Exon-Exon chr20:33067500-33095713 chr20:34479695-34507908 382 nt 0.4084
Showing 231 to 240 of 255 entries
Forensic Context

A review consolidating research in humans and model organisms indicates that the circITCH functions as a tumor suppressor in glioma by sponging miR-214 to allow expression of ubiquitin-protein ligase E3, thereby suppressing proliferation and preventing apoptosis, while also targeting the Wnt/β-catenin pathway [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746]. In oesophageal squamous cell carcinoma, the circITCH is downregulated and increases ITCH expression to inhibit the Wnt/β-catenin pathway [Lee et al. DOI:10.1016/j.biopha.2018.12.052]. circITCH hsa_circ_0001141 (circITCH) was found to be lower in the hearts of cancer patients suffering from doxorubicin-induced cardiomyopathy compared to those with dilated cardiomyopathy, hypertrophic cardiomyopathy, and healthy donors, and its expression ameliorates doxorubicin-induced cardiomyocyte injury [Tian et al. DOI:10.3390/molecules26041155].