Basic Information

Symbol
circITCH
RNA Class
circRNA
Alias
Itchy E3 Ubiquitin Protein Ligase AIP4 HECT-Type E3 Ubiquitin Transferase Itchy Homolog E3 Ubiquitin-Protein Ligase Itchy Homolog NFE2-Associated Polypeptide 1 NAPP1 Itchy (Mouse Homolog) E3 Ubiquitin Protein Ligase Itchy E3 Ubiquitin Protein Ligase Homolog (Mouse) Itchy E3 Ubiquitin Protein Ligase Homolog Atrophin-1 Interacting Protein 4 Atrophin-1-Interacting Protein 4 EC 2.3.2.26 EC 6.3.2 ADMFD AIF4 Itch
Location (GRCh37)
20:32951062-33099197 UCSC Genome Browser
Location (GRCh38)
20:34363256-34511392
UCSC Genome Browser Search in Marker Scope
Host gene
ITCH
Host category
mRNA
Forensic tag(s)
Other applications
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_ITCH_0029300 Exon-Exon chr20:33068404-33095713 chr20:34480599-34507908 885 nt 0.3910
hsa_ITCH_0029500 Exon-Exon chr20:33068404-33097632 chr20:34480599-34509827 134 nt 0.3657
hsa_ITCH_0029800 Exon-Exon chr20:33068987-33095713 chr20:34481182-34507908 25 nt 0.2800
hsa_ITCH_0029900 Intron-Exon-Intron chr20:33077048-33092208 chr20:34489243-34504403 419 nt 0.4033
hsa_ITCH_0030400 Exon-Exon chr20:33077071-33095713 chr20:34489266-34507908 218 nt 0.3991
hsa_ITCH_0030500 Exon-Exon chr20:33077071-33097632 chr20:34489266-34509827 97 nt 0.4021
hsa_ITCH_0030800 Exon-Exon chr20:33080333-33092208 chr20:34492528-34504403 143 nt 0.4476
hsa_ITCH_0030900 Intron-Intron chr20:33091033-33092013 chr20:34503228-34504208 981 nt 0.3741
hsa_ITCH_0031100 Exon-Exon chr20:33092136-33095713 chr20:34504331-34507908 287 nt 0.4146
hsa_chr20_0093600 Intergenic-Intergenic chr20:33095516-33095656 chr20:34507711-34507851 141 nt 0.4113
Showing 241 to 250 of 255 entries
Forensic Context

A review consolidating research in humans and model organisms indicates that the circITCH functions as a tumor suppressor in glioma by sponging miR-214 to allow expression of ubiquitin-protein ligase E3, thereby suppressing proliferation and preventing apoptosis, while also targeting the Wnt/β-catenin pathway [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746]. In oesophageal squamous cell carcinoma, the circITCH is downregulated and increases ITCH expression to inhibit the Wnt/β-catenin pathway [Lee et al. DOI:10.1016/j.biopha.2018.12.052]. circITCH hsa_circ_0001141 (circITCH) was found to be lower in the hearts of cancer patients suffering from doxorubicin-induced cardiomyopathy compared to those with dilated cardiomyopathy, hypertrophic cardiomyopathy, and healthy donors, and its expression ameliorates doxorubicin-induced cardiomyocyte injury [Tian et al. DOI:10.3390/molecules26041155].