Basic Information

Symbol
circITCH
RNA Class
circRNA
Alias
Itchy E3 Ubiquitin Protein Ligase AIP4 HECT-Type E3 Ubiquitin Transferase Itchy Homolog E3 Ubiquitin-Protein Ligase Itchy Homolog NFE2-Associated Polypeptide 1 NAPP1 Itchy (Mouse Homolog) E3 Ubiquitin Protein Ligase Itchy E3 Ubiquitin Protein Ligase Homolog (Mouse) Itchy E3 Ubiquitin Protein Ligase Homolog Atrophin-1 Interacting Protein 4 Atrophin-1-Interacting Protein 4 EC 2.3.2.26 EC 6.3.2 ADMFD AIF4 Itch
Location (GRCh37)
20:32951062-33099197 UCSC Genome Browser
Location (GRCh38)
20:34363256-34511392
UCSC Genome Browser Search in Marker Scope
Host gene
ITCH
Host category
mRNA
Forensic tag(s)
Other applications
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_ITCH_0010600 Exon-Exon chr20:33001548-33057925 chr20:34413742-34470120 1160 nt 0.4509
hsa_ITCH_0009400 Exon-Exon chr20:33001548-33069011 chr20:34413742-34481206 1879 nt 0.4343
hsa_ITCH_0009500 Exon-Exon chr20:33001548-33080402 chr20:34413742-34492597 2202 nt 0.4301
hsa_ITCH_0013100 Exon-Exon chr20:33012286-33026436 chr20:34424480-34438631 204 nt 0.4804
hsa_ITCH_0013200 Exon-Exon chr20:33012286-33030108 chr20:34424480-34442303 490 nt 0.4735
hsa_ITCH_0016000 Exon-Exon chr20:33026279-33028149 chr20:34438474-34440344 348 nt 0.4713
hsa_ITCH_0016100 Exon-Exon chr20:33026279-33037285 chr20:34438474-34449480 689 nt 0.4659
hsa_ITCH_0016200 Exon-Exon chr20:33026279-33059320 chr20:34438474-34471515 1048 nt 0.4532
hsa_ITCH_0016300 Exon-Exon chr20:33026279-33080402 chr20:34438474-34492597 1895 nt 0.4232
hsa_ITCH_0017400 Exon-Exon chr20:33027960-33028149 chr20:34440155-34440344 190 nt 0.4579
Showing 21 to 30 of 255 entries
Forensic Context

A review consolidating research in humans and model organisms indicates that the circITCH functions as a tumor suppressor in glioma by sponging miR-214 to allow expression of ubiquitin-protein ligase E3, thereby suppressing proliferation and preventing apoptosis, while also targeting the Wnt/β-catenin pathway [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746]. In oesophageal squamous cell carcinoma, the circITCH is downregulated and increases ITCH expression to inhibit the Wnt/β-catenin pathway [Lee et al. DOI:10.1016/j.biopha.2018.12.052]. circITCH hsa_circ_0001141 (circITCH) was found to be lower in the hearts of cancer patients suffering from doxorubicin-induced cardiomyopathy compared to those with dilated cardiomyopathy, hypertrophic cardiomyopathy, and healthy donors, and its expression ameliorates doxorubicin-induced cardiomyocyte injury [Tian et al. DOI:10.3390/molecules26041155].