Basic Information

Symbol
circITCH
RNA Class
circRNA
Alias
Itchy E3 Ubiquitin Protein Ligase AIP4 HECT-Type E3 Ubiquitin Transferase Itchy Homolog E3 Ubiquitin-Protein Ligase Itchy Homolog NFE2-Associated Polypeptide 1 NAPP1 Itchy (Mouse Homolog) E3 Ubiquitin Protein Ligase Itchy E3 Ubiquitin Protein Ligase Homolog (Mouse) Itchy E3 Ubiquitin Protein Ligase Homolog Atrophin-1 Interacting Protein 4 Atrophin-1-Interacting Protein 4 EC 2.3.2.26 EC 6.3.2 ADMFD AIF4 Itch
Location (GRCh37)
20:32951062-33099197 UCSC Genome Browser
Location (GRCh38)
20:34363256-34511392
UCSC Genome Browser Search in Marker Scope
Host gene
ITCH
Host category
mRNA
Forensic tag(s)
Other applications
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_ITCH_0017500 Exon-Exon chr20:33027960-33030108 chr20:34440155-34442303 286 nt 0.4685
hsa_ITCH_0017600 Exon-Exon chr20:33027960-33037285 chr20:34440155-34449480 531 nt 0.4595
hsa_ITCH_0017700 Exon-Exon chr20:33027960-33045279 chr20:34440155-34457474 616 nt 0.4578
hsa_ITCH_0017800 Exon-Exon chr20:33027960-33050026 chr20:34440155-34462221 745 nt 0.4497
hsa_ITCH_0017900 Exon-Exon chr20:33027960-33059320 chr20:34440155-34471515 890 nt 0.4472
hsa_ITCH_0018000 Exon-Exon chr20:33027960-33067594 chr20:34440155-34479789 1139 nt 0.4372
hsa_ITCH_0018100 Exon-Exon chr20:33027960-33069011 chr20:34440155-34481206 1414 nt 0.4201
hsa_ITCH_0018800 Exon-Exon chr20:33030013-33033266 chr20:34442208-34445461 271 nt 0.4797
hsa_ITCH_0018900 Exon-Exon chr20:33030013-33037285 chr20:34442208-34449480 341 nt 0.4604
hsa_ITCH_0019000 Exon-Exon chr20:33030013-33050026 chr20:34442208-34462221 555 nt 0.4468
Showing 31 to 40 of 255 entries
Forensic Context

A review consolidating research in humans and model organisms indicates that the circITCH functions as a tumor suppressor in glioma by sponging miR-214 to allow expression of ubiquitin-protein ligase E3, thereby suppressing proliferation and preventing apoptosis, while also targeting the Wnt/β-catenin pathway [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746]. In oesophageal squamous cell carcinoma, the circITCH is downregulated and increases ITCH expression to inhibit the Wnt/β-catenin pathway [Lee et al. DOI:10.1016/j.biopha.2018.12.052]. circITCH hsa_circ_0001141 (circITCH) was found to be lower in the hearts of cancer patients suffering from doxorubicin-induced cardiomyopathy compared to those with dilated cardiomyopathy, hypertrophic cardiomyopathy, and healthy donors, and its expression ameliorates doxorubicin-induced cardiomyocyte injury [Tian et al. DOI:10.3390/molecules26041155].