Basic Information

Symbol
circITCH
RNA Class
circRNA
Alias
Itchy E3 Ubiquitin Protein Ligase AIP4 HECT-Type E3 Ubiquitin Transferase Itchy Homolog E3 Ubiquitin-Protein Ligase Itchy Homolog NFE2-Associated Polypeptide 1 NAPP1 Itchy (Mouse Homolog) E3 Ubiquitin Protein Ligase Itchy E3 Ubiquitin Protein Ligase Homolog (Mouse) Itchy E3 Ubiquitin Protein Ligase Homolog Atrophin-1 Interacting Protein 4 Atrophin-1-Interacting Protein 4 EC 2.3.2.26 EC 6.3.2 ADMFD AIF4 Itch
Location (GRCh37)
20:32951062-33099197 UCSC Genome Browser
Location (GRCh38)
20:34363256-34511392
UCSC Genome Browser Search in Marker Scope
Host gene
ITCH
Host category
mRNA
Forensic tag(s)
Other applications
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_ITCH_0019100 Exon-Exon chr20:33030013-33080402 chr20:34442208-34492597 1547 nt 0.4124
hsa_ITCH_0019800 Exon-Exon chr20:33033092-33099197 chr20:34445287-34511392 250 nt 0.3440
hsa_ITCH_0021500 Exon-Exon chr20:33045195-33057925 chr20:34457390-34470120 287 nt 0.4355
hsa_ITCH_0021600 Exon-Exon chr20:33045195-33059320 chr20:34457390-34471515 359 nt 0.4290
hsa_ITCH_0021700 Exon-Exon chr20:33045195-33069011 chr20:34457390-34481206 883 nt 0.3964
hsa_ITCH_0021800 Exon-Exon chr20:33045195-33080402 chr20:34457390-34492597 1206 nt 0.3988
hsa_ITCH_0021900 Exon-Exon chr20:33045195-33095713 chr20:34457390-34507908 1493 nt 0.4019
hsa_ITCH_0022900 Exon-Exon chr20:33049898-33057925 chr20:34462093-34470120 202 nt 0.4307
hsa_ITCH_0023000 Exon-Exon chr20:33049898-33092208 chr20:34462093-34504403 1194 nt 0.3970
hsa_ITCH_0024000 Exon-Exon chr20:33057853-33059320 chr20:34470048-34471515 145 nt 0.4345
Showing 41 to 50 of 255 entries
Forensic Context

A review consolidating research in humans and model organisms indicates that the circITCH functions as a tumor suppressor in glioma by sponging miR-214 to allow expression of ubiquitin-protein ligase E3, thereby suppressing proliferation and preventing apoptosis, while also targeting the Wnt/β-catenin pathway [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746]. In oesophageal squamous cell carcinoma, the circITCH is downregulated and increases ITCH expression to inhibit the Wnt/β-catenin pathway [Lee et al. DOI:10.1016/j.biopha.2018.12.052]. circITCH hsa_circ_0001141 (circITCH) was found to be lower in the hearts of cancer patients suffering from doxorubicin-induced cardiomyopathy compared to those with dilated cardiomyopathy, hypertrophic cardiomyopathy, and healthy donors, and its expression ameliorates doxorubicin-induced cardiomyocyte injury [Tian et al. DOI:10.3390/molecules26041155].