Basic Information

Symbol
circITCH
RNA Class
circRNA
Alias
Itchy E3 Ubiquitin Protein Ligase AIP4 HECT-Type E3 Ubiquitin Transferase Itchy Homolog E3 Ubiquitin-Protein Ligase Itchy Homolog NFE2-Associated Polypeptide 1 NAPP1 Itchy (Mouse Homolog) E3 Ubiquitin Protein Ligase Itchy E3 Ubiquitin Protein Ligase Homolog (Mouse) Itchy E3 Ubiquitin Protein Ligase Homolog Atrophin-1 Interacting Protein 4 Atrophin-1-Interacting Protein 4 EC 2.3.2.26 EC 6.3.2 ADMFD AIF4 Itch
Location (GRCh37)
20:32951062-33099197 UCSC Genome Browser
Location (GRCh38)
20:34363256-34511392
UCSC Genome Browser Search in Marker Scope
Host gene
ITCH
Host category
mRNA
Forensic tag(s)
Other applications
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_ITCH_0024100 Exon-Exon chr20:33057853-33069011 chr20:34470048-34481206 669 nt 0.3871
hsa_ITCH_0024200 Exon-Exon chr20:33057853-33077731 chr20:34470048-34489926 895 nt 0.3922
hsa_ITCH_0024300 Exon-Exon chr20:33057853-33080402 chr20:34470048-34492597 992 nt 0.3931
hsa_ITCH_0026600 Exon-Exon chr20:33059249-33067594 chr20:34471444-34479789 367 nt 0.3951
hsa_ITCH_0026200 Exon-Exon chr20:33059249-33069011 chr20:34471444-34481206 596 nt 0.3775
hsa_ITCH_0026300 Exon-Exon chr20:33059249-33080402 chr20:34471444-34492597 919 nt 0.3874
hsa_ITCH_0026400 Exon-Exon chr20:33059249-33095713 chr20:34471444-34507908 1206 nt 0.3939
hsa_ITCH_0027000 Exon-Exon chr20:33065577-33067594 chr20:34477772-34479789 249 nt 0.4016
hsa_ITCH_0027100 Exon-Exon chr20:33065577-33068537 chr20:34477772-34480732 383 nt 0.3890
hsa_ITCH_0027200 Exon-Exon chr20:33065577-33069011 chr20:34477772-34481206 524 nt 0.3740
Showing 51 to 60 of 255 entries
Forensic Context

A review consolidating research in humans and model organisms indicates that the circITCH functions as a tumor suppressor in glioma by sponging miR-214 to allow expression of ubiquitin-protein ligase E3, thereby suppressing proliferation and preventing apoptosis, while also targeting the Wnt/β-catenin pathway [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746]. In oesophageal squamous cell carcinoma, the circITCH is downregulated and increases ITCH expression to inhibit the Wnt/β-catenin pathway [Lee et al. DOI:10.1016/j.biopha.2018.12.052]. circITCH hsa_circ_0001141 (circITCH) was found to be lower in the hearts of cancer patients suffering from doxorubicin-induced cardiomyopathy compared to those with dilated cardiomyopathy, hypertrophic cardiomyopathy, and healthy donors, and its expression ameliorates doxorubicin-induced cardiomyocyte injury [Tian et al. DOI:10.3390/molecules26041155].