Basic Information

Symbol
circITCH
RNA Class
circRNA
Alias
Itchy E3 Ubiquitin Protein Ligase AIP4 HECT-Type E3 Ubiquitin Transferase Itchy Homolog E3 Ubiquitin-Protein Ligase Itchy Homolog NFE2-Associated Polypeptide 1 NAPP1 Itchy (Mouse Homolog) E3 Ubiquitin Protein Ligase Itchy E3 Ubiquitin Protein Ligase Homolog (Mouse) Itchy E3 Ubiquitin Protein Ligase Homolog Atrophin-1 Interacting Protein 4 Atrophin-1-Interacting Protein 4 EC 2.3.2.26 EC 6.3.2 ADMFD AIF4 Itch
Location (GRCh37)
20:32951062-33099197 UCSC Genome Browser
Location (GRCh38)
20:34363256-34511392
UCSC Genome Browser Search in Marker Scope
Host gene
ITCH
Host category
mRNA
Forensic tag(s)
Other applications
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_ITCH_0027300 Exon-Exon chr20:33065577-33092208 chr20:34477772-34504403 920 nt 0.3891
hsa_ITCH_0027400 Exon-Exon chr20:33065577-33099197 chr20:34477772-34511392 250 nt 0.3160
hsa_ITCH_0028100 Exon-Exon chr20:33067435-33069011 chr20:34479630-34481206 435 nt 0.3609
hsa_ITCH_0029000 Exon-Exon chr20:33068404-33069011 chr20:34480599-34481206 275 nt 0.3491
hsa_ITCH_0029100 Exon-Exon chr20:33068404-33099197 chr20:34480599-34511392 250 nt 0.2960
hsa_ITCH_0030000 Exon-Exon chr20:33077071-33080402 chr20:34489266-34492597 323 nt 0.4056
hsa_ITCH_0030100 Exon-Exon chr20:33077071-33092208 chr20:34489266-34504403 396 nt 0.4091
hsa_ITCH_0030700 Exon-Exon chr20:33080306-33092208 chr20:34492501-34504403 170 nt 0.4118
hsa_ITCH_0000400 Intron-Exon-Intron chr20:32951825-32996598 chr20:34364019-34408792 250 nt 0.3440
hsa_ITCH_0000500 Intron-Exon-Intron chr20:32953266-32957276 chr20:34365460-34369470 194 nt 0.5619
Showing 61 to 70 of 255 entries
Forensic Context

A review consolidating research in humans and model organisms indicates that the circITCH functions as a tumor suppressor in glioma by sponging miR-214 to allow expression of ubiquitin-protein ligase E3, thereby suppressing proliferation and preventing apoptosis, while also targeting the Wnt/β-catenin pathway [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746]. In oesophageal squamous cell carcinoma, the circITCH is downregulated and increases ITCH expression to inhibit the Wnt/β-catenin pathway [Lee et al. DOI:10.1016/j.biopha.2018.12.052]. circITCH hsa_circ_0001141 (circITCH) was found to be lower in the hearts of cancer patients suffering from doxorubicin-induced cardiomyopathy compared to those with dilated cardiomyopathy, hypertrophic cardiomyopathy, and healthy donors, and its expression ameliorates doxorubicin-induced cardiomyocyte injury [Tian et al. DOI:10.3390/molecules26041155].