Basic Information

Symbol
circITCH
RNA Class
circRNA
Alias
Itchy E3 Ubiquitin Protein Ligase AIP4 HECT-Type E3 Ubiquitin Transferase Itchy Homolog E3 Ubiquitin-Protein Ligase Itchy Homolog NFE2-Associated Polypeptide 1 NAPP1 Itchy (Mouse Homolog) E3 Ubiquitin Protein Ligase Itchy E3 Ubiquitin Protein Ligase Homolog (Mouse) Itchy E3 Ubiquitin Protein Ligase Homolog Atrophin-1 Interacting Protein 4 Atrophin-1-Interacting Protein 4 EC 2.3.2.26 EC 6.3.2 ADMFD AIF4 Itch
Location (GRCh37)
20:32951062-33099197 UCSC Genome Browser
Location (GRCh38)
20:34363256-34511392
UCSC Genome Browser Search in Marker Scope
Host gene
ITCH
Host category
mRNA
Forensic tag(s)
Other applications
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_ITCH_0000600 Intron-Exon-Intron chr20:32953266-32996598 chr20:34365460-34408792 142 nt 0.4085
hsa_ITCH_0000700 Intron-Exon-Intron chr20:32953266-33000445 chr20:34365460-34412639 117 nt 0.6068
hsa_ITCH_0000800 Intron-Exon-Intron chr20:32953266-33012331 chr20:34365460-34424525 184 nt 0.4185
hsa_ITCH_0000900 Intron-Exon-Intron chr20:32956921-32972684 chr20:34369115-34384878 250 nt 0.4160
hsa_ITCH_0001700 Intron-Exon-Intron chr20:32957200-32980720 chr20:34369394-34392914 255 nt 0.5765
hsa_ITCH_0001800 Intron-Exon-Intron chr20:32957200-32985127 chr20:34369394-34397321 114 nt 0.6053
hsa_ITCH_0001900 Exon-Exon chr20:32957200-33000445 chr20:34369394-34412639 310 nt 0.4419
hsa_ITCH_0002000 Exon-Exon chr20:32957200-33012331 chr20:34369394-34424525 123 nt 0.4797
hsa_ITCH_0001500 Exon-Exon chr20:32957200-33026436 chr20:34369394-34438631 900 nt 0.4478
hsa_ITCH_0001600 Exon-Exon chr20:32957200-33050026 chr20:34369394-34462221 1645 nt 0.4486
Showing 71 to 80 of 255 entries
Forensic Context

A review consolidating research in humans and model organisms indicates that the circITCH functions as a tumor suppressor in glioma by sponging miR-214 to allow expression of ubiquitin-protein ligase E3, thereby suppressing proliferation and preventing apoptosis, while also targeting the Wnt/β-catenin pathway [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746]. In oesophageal squamous cell carcinoma, the circITCH is downregulated and increases ITCH expression to inhibit the Wnt/β-catenin pathway [Lee et al. DOI:10.1016/j.biopha.2018.12.052]. circITCH hsa_circ_0001141 (circITCH) was found to be lower in the hearts of cancer patients suffering from doxorubicin-induced cardiomyopathy compared to those with dilated cardiomyopathy, hypertrophic cardiomyopathy, and healthy donors, and its expression ameliorates doxorubicin-induced cardiomyocyte injury [Tian et al. DOI:10.3390/molecules26041155].