Basic Information

Symbol
circITCH
RNA Class
circRNA
Alias
Itchy E3 Ubiquitin Protein Ligase AIP4 HECT-Type E3 Ubiquitin Transferase Itchy Homolog E3 Ubiquitin-Protein Ligase Itchy Homolog NFE2-Associated Polypeptide 1 NAPP1 Itchy (Mouse Homolog) E3 Ubiquitin Protein Ligase Itchy E3 Ubiquitin Protein Ligase Homolog (Mouse) Itchy E3 Ubiquitin Protein Ligase Homolog Atrophin-1 Interacting Protein 4 Atrophin-1-Interacting Protein 4 EC 2.3.2.26 EC 6.3.2 ADMFD AIF4 Itch
Location (GRCh37)
20:32951062-33099197 UCSC Genome Browser
Location (GRCh38)
20:34363256-34511392
UCSC Genome Browser Search in Marker Scope
Host gene
ITCH
Host category
mRNA
Forensic tag(s)
Other applications
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_ITCH_0002300 Exon-Exon chr20:32957200-33069011 chr20:34369394-34481206 309 nt 0.4078
hsa_ITCH_0001400 Exon-Exon chr20:32957200-33080402 chr20:34369394-34492597 2637 nt 0.4278
hsa_ITCH_0002500 Intron-Intron chr20:32958257-32971377 chr20:34370451-34383571 250 nt 0.3680
hsa_ITCH_0002600 Intron-Intron chr20:32958512-32958667 chr20:34370706-34370861 156 nt 0.3782
hsa_ITCH_0002700 Intron-Intron chr20:32966064-32971377 chr20:34378258-34383571 250 nt 0.3960
hsa_chr20_0092300 Intergenic-Intergenic chr20:32966246-32967273 chr20:34378440-34379467 1028 nt 0.3191
hsa_ITCH_0002800 Intron-Intron chr20:32971450-32974832 chr20:34383644-34387026 250 nt 0.2920
hsa_chr20_0092400 Intergenic-Intergenic chr20:32972701-32974890 chr20:34384895-34387084 2190 nt 0.3886
hsa_chr20_0092600 Intergenic-Intergenic chr20:32978532-32978911 chr20:34390726-34391105 380 nt 0.4737
hsa_ITCH_0003000 Intron-Exon-Intron chr20:32980327-33001685 chr20:34392521-34413879 1766 nt 0.4094
Showing 81 to 90 of 255 entries
Forensic Context

A review consolidating research in humans and model organisms indicates that the circITCH functions as a tumor suppressor in glioma by sponging miR-214 to allow expression of ubiquitin-protein ligase E3, thereby suppressing proliferation and preventing apoptosis, while also targeting the Wnt/β-catenin pathway [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746]. In oesophageal squamous cell carcinoma, the circITCH is downregulated and increases ITCH expression to inhibit the Wnt/β-catenin pathway [Lee et al. DOI:10.1016/j.biopha.2018.12.052]. circITCH hsa_circ_0001141 (circITCH) was found to be lower in the hearts of cancer patients suffering from doxorubicin-induced cardiomyopathy compared to those with dilated cardiomyopathy, hypertrophic cardiomyopathy, and healthy donors, and its expression ameliorates doxorubicin-induced cardiomyocyte injury [Tian et al. DOI:10.3390/molecules26041155].