Basic Information

Symbol
circKLHL1
RNA Class
circRNA
Alias
Kelch Like Family Member 1 Kelch-Like Protein 1 KIAA1490 MRP2 Mayven-Related Protein 2 FLJ30047 Kelch (Drosophila)-Like 1 Kelch-Like 1 (Drosophila)
Location (GRCh37)
13:70281757-70681526 UCSC Genome Browser
Location (GRCh38)
13:69707625-70107394
UCSC Genome Browser Search in Marker Scope
Host gene
KLHL1
Host category
mRNA
Forensic tag(s)
Sudden death from CNS diseases
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_KLHL1_0005000 Intron-Exon-Intron chr13:70535440-70655745 chr13:69961308-70081613 250 nt 0.3640
hsa_KLHL1_0005100 Intron-Exon-Intron chr13:70535440-70668429 chr13:69961308-70094297 250 nt 0.4040
hsa_KLHL1_0005200 Intron-Intron chr13:70544180-70545073 chr13:69970048-69970941 894 nt 0.4049
hsa_KLHL1_0005300 Exon-Exon chr13:70549752-70549934 chr13:69975620-69975802 183 nt 0.4262
hsa_KLHL1_0005400 Intron-Exon-Intron chr13:70549752-70568930 chr13:69975620-69994798 99 nt 0.3838
hsa_chr13_0246100 Intergenic-Intergenic chr13:70590155-70590967 chr13:70016023-70016835 813 nt 0.5314
hsa_chr13_0246200 Intergenic-Intergenic chr13:70621079-70621362 chr13:70046947-70047230 284 nt 0.3415
hsa_KLHL1_0005500 Intron-Intron chr13:70636275-70637155 chr13:70062143-70063023 881 nt 0.2770
hsa_KLHL1_0005600 Intron-Intron chr13:70638508-70638818 chr13:70064376-70064686 311 nt 0.3312
hsa_KLHL1_0005700 Intron-Intron chr13:70642571-70642773 chr13:70068439-70068641 203 nt 0.3153
Showing 51 to 60 of 64 entries
Forensic Context

A study in humans identified the circKLHL1 as a potential biomarker for immune-mediated demyelinating disease, where its levels in cerebrospinal fluid exosomes were specifically noted [Misir et al. DOI:10.1038/s41418-022-00948-7]. A review of literature indicates that the circKLHL1 is a synaptically-enriched circular RNA abundant in the dendritic arbor of neurons, suggesting a role in synaptic function [Suresh L. Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].