Basic Information
Symbol
circKLHL2
RNA Class
circRNA
Alias
Kelch Like Family Member 2
MAV
Actin-Binding Protein Mayven
Kelch-Like Protein 2
Mayven
Kelch (Drosophila)-Like 2 (Mayven)
Kelch-Like 2, Mayven (Drosophila)
Kelch-Like 2, Mayven
ABP-KELCH
Location (GRCh37)
4:166131171-166239121
UCSC Genome Browser
Location (GRCh38)
4:165210019-165317969
Host gene
KLHL2
Host category
mRNA
Forensic tag(s)
Sudden death from CNS diseases
Cause of death analysis
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_KLHL2_0000300 | Intron-Exon-Intron | chr4:166139177-166150065 | chr4:165218025-165228913 | 107 nt | 0.4393 |
| hsa_KLHL2_0000400 | Intron-Exon-Intron | chr4:166139177-166160051 | chr4:165218025-165238899 | 313 nt | 0.4281 |
| hsa_KLHL2_0000500 | Intron-Exon-Intron | chr4:166139177-166198695 | chr4:165218025-165277543 | 424 nt | 0.4292 |
| hsa_KLHL2_0000600 | Intron-Exon-Intron | chr4:166139177-166220808 | chr4:165218025-165299656 | 126 nt | 0.4048 |
| hsa_KLHL2_0000700 | Intron-Exon-Intron | chr4:166139397-166150065 | chr4:165218245-165228913 | 239 nt | 0.4226 |
| hsa_KLHL2_0000800 | Intron-Exon-Intron | chr4:166139397-166160051 | chr4:165218245-165238899 | 256 nt | 0.4609 |
| hsa_KLHL2_0000900 | Intron-Exon-Intron | chr4:166139397-166220808 | chr4:165218245-165299656 | 267 nt | 0.4569 |
| hsa_KLHL2_0001000 | Exon-Exon | chr4:166140796-166160051 | chr4:165219644-165238899 | 79 nt | 0.4177 |
| hsa_KLHL2_0001100 | Intron-Exon-Intron | chr4:166140796-166184511 | chr4:165219644-165263359 | 490 nt | 0.4306 |
| hsa_KLHL2_0001900 | Intron-Exon-Intron | chr4:166141086-166170298 | chr4:165219934-165249146 | 250 nt | 0.3520 |
Showing 21 to 30 of 64 entries
Forensic Context
A study in humans identified the circKLHL2 as a potential biomarker for immune-mediated demyelinating disease, where its levels in cerebrospinal fluid exosomes were specifically characterized [Misir et al. DOI:10.1038/s41418-022-00948-7]. A study in mice and human patients demonstrated that the circKLHL2 may expedite sepsis-induced acute lung injury by adjusting the miR-29b-3p/ROCK axis [Xu et al. DOI:10.1080/01902148.2024.2429184].