Basic Information
Symbol
circMBL2
RNA Class
circRNA
Alias
Mannose Binding Lectin 2
COLEC1
MBP-C
MBP1
MBP
MBL
Mannose-Binding Lectin (Protein C) 2, Soluble (Opsonic Defect)
Mannose-Binding Protein C
Collectin-1
Mannose-Binding Lectin 2, Soluble (Opsonic Defect)
Mannose-Binding Lectin (Protein C) 2, Soluble
Mannose-Binding Protein
Mannan-Binding Protein
Mannose-Binding Lectin
Mannan-Binding Lectin
Collectin 1
HSMBPC
MBL2D
MBPD
Location (GRCh37)
10:54527914-54529075
UCSC Genome Browser
Location (GRCh38)
10:52768154-52769315
Host gene
MBL2
Host category
mRNA
Forensic tag(s)
Other applications
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_MBL2_0000100 | Exon-Exon | chr10:54527914-54529075 | chr10:52768154-52769315 | 426 nt | 0.4859 |
| hsa_chr10_0342800 | Intergenic-Intergenic | chr10:54527931-54528152 | chr10:52768171-52768392 | 222 nt | 0.4910 |
Forensic Context
A study in Drosophila demonstrated that the circMBL2 regulates gene expression and its knockdown leads to male lethality, behavioral defects, and synaptic dysfunction [Patop et al. DOI:10.15252/embj.2018100836]. The circMBL2 is also noted for its role in brain development and CNS diseases, with its expression being synaptically-enriched and involved in neuronal plasticity [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746]. Another review notes the circMBL2 functions as a splicing competitor, adversely affecting canonical splicing by competing with pre-MBL mRNA splicing [Misir et al. DOI:10.1038/s41418-022-00948-7].