Basic Information

Symbol
circMBNL1
RNA Class
circRNA
Alias
Muscleblind Like Splicing Regulator 1 EXP KIAA0428 MBNL Triplet-Expansion RNA-Binding Protein Muscleblind-Like Protein 1 EXP42 EXP40 EXP35 Muscleblind-Like Splicing Regulator 1 Muscleblind (Drosophila)-Like Muscleblind-Like (Drosophila) Muscleblind-Like
Location (GRCh37)
3:151961621-152183569 UCSC Genome Browser
Location (GRCh38)
3:152243832-152465780
UCSC Genome Browser Search in Marker Scope
Host gene
MBNL1
Host category
mRNA
Forensic tag(s)
Other applications
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_MBNL1_0000900 Exon-Exon chr3:151985829-152018156 chr3:152268040-152300367 2016 nt 0.4866
hsa_MBNL1_0002100 Intron-Exon-Intron chr3:152016771-152018156 chr3:152298982-152300367 1386 nt 0.4214
hsa_MBNL1_0002200 Exon-Exon chr3:152017194-152018156 chr3:152299405-152300367 963 nt 0.4247
hsa_MBNL1_0003200 Exon-Exon chr3:152017194-152183569 chr3:152299405-152465780 250 nt 0.3120
hsa_chr3_0289300 Intergenic-Intergenic chr3:152031193-152031396 chr3:152313404-152313607 204 nt 0.3480
hsa_MBNL1_0011600 Exon-Exon chr3:152132730-152150709 chr3:152414941-152432920 375 nt 0.5120
hsa_MBNL1_0012500 Exon-Exon chr3:152132730-152165562 chr3:152414941-152447773 841 nt 0.5054
hsa_MBNL1_0014400 Exon-Exon chr3:152163071-152165562 chr3:152445282-152447773 466 nt 0.5000
hsa_MBNL1_0014900 Exon-Exon chr3:152164493-152174150 chr3:152446704-152456361 303 nt 0.5248
hsa_MBNL1_0015400 Exon-Exon chr3:152173331-152174150 chr3:152455542-152456361 131 nt 0.5573
Showing 1 to 10 of 186 entries
Forensic Context

A study in mice and Drosophila demonstrated that the circMBNL1 regulates the production of its linear mRNA counterpart in cis through competition with canonical splicing [Patop et al. DOI:10.15252/embj.2018100836]. A separate review confirmed its role as a splicing competitor that adversely affects canonical pre-mRNA splicing [Misir et al. DOI:10.1038/s41418-022-00948-7]. Research in mammalian neural tissue indicates that the circMBNL1 is synaptically-enriched and abundant in the dendritic arbor, suggesting a role in synaptic function [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].