Basic Information

Symbol
circMBNL1
RNA Class
circRNA
Alias
Muscleblind Like Splicing Regulator 1 EXP KIAA0428 MBNL Triplet-Expansion RNA-Binding Protein Muscleblind-Like Protein 1 EXP42 EXP40 EXP35 Muscleblind-Like Splicing Regulator 1 Muscleblind (Drosophila)-Like Muscleblind-Like (Drosophila) Muscleblind-Like
Location (GRCh37)
3:151961621-152183569 UCSC Genome Browser
Location (GRCh38)
3:152243832-152465780
UCSC Genome Browser Search in Marker Scope
Host gene
MBNL1
Host category
mRNA
Forensic tag(s)
Other applications
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_MBNL1_0007800 Exon-Exon chr3:152052900-152165562 chr3:152335111-152447773 291 nt 0.4674
hsa_MBNL1_0007900 Intron-Intron chr3:152055609-152056462 chr3:152337820-152338673 854 nt 0.4110
hsa_MBNL1_0008000 Intron-Exon-Intron chr3:152055907-152132900 chr3:152338118-152415111 250 nt 0.3640
hsa_MBNL1_0008100 Intron-Exon-Intron chr3:152055907-152165562 chr3:152338118-152447773 154 nt 0.4740
hsa_MBNL1_0008200 Intron-Exon-Intron chr3:152055907-152173366 chr3:152338118-152455577 244 nt 0.4918
hsa_MBNL1_0008300 Intron-Intron chr3:152058734-152059283 chr3:152340945-152341494 550 nt 0.2855
hsa_chr3_0289700 Intergenic-Intergenic chr3:152060097-152060395 chr3:152342308-152342606 299 nt 0.3746
hsa_MBNL1_0008400 Intron-Exon-Intron chr3:152061070-152132900 chr3:152343281-152415111 163 nt 0.4785
hsa_MBNL1_0008500 Intron-Intron chr3:152061961-152063966 chr3:152344172-152346177 2006 nt 0.3500
hsa_MBNL1_0008600 Intron-Intron chr3:152062186-152062810 chr3:152344397-152345021 625 nt 0.3568
Showing 91 to 100 of 186 entries
Forensic Context

A study in mice and Drosophila demonstrated that the circMBNL1 regulates the production of its linear mRNA counterpart in cis through competition with canonical splicing [Patop et al. DOI:10.15252/embj.2018100836]. A separate review confirmed its role as a splicing competitor that adversely affects canonical pre-mRNA splicing [Misir et al. DOI:10.1038/s41418-022-00948-7]. Research in mammalian neural tissue indicates that the circMBNL1 is synaptically-enriched and abundant in the dendritic arbor, suggesting a role in synaptic function [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].