Basic Information

Symbol
circMBNL1
RNA Class
circRNA
Alias
Muscleblind Like Splicing Regulator 1 EXP KIAA0428 MBNL Triplet-Expansion RNA-Binding Protein Muscleblind-Like Protein 1 EXP42 EXP40 EXP35 Muscleblind-Like Splicing Regulator 1 Muscleblind (Drosophila)-Like Muscleblind-Like (Drosophila) Muscleblind-Like
Location (GRCh37)
3:151961621-152183569 UCSC Genome Browser
Location (GRCh38)
3:152243832-152465780
UCSC Genome Browser Search in Marker Scope
Host gene
MBNL1
Host category
mRNA
Forensic tag(s)
Other applications
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_MBNL1_0008700 Intron-Exon-Intron chr3:152063127-152133246 chr3:152345338-152415457 85 nt 0.3882
hsa_MBNL1_0008800 Intron-Intron chr3:152065464-152065801 chr3:152347675-152348012 338 nt 0.3077
hsa_MBNL1_0008900 Intron-Intron chr3:152065802-152066480 chr3:152348013-152348691 679 nt 0.3122
hsa_MBNL1_0009000 Intron-Intron chr3:152065814-152066586 chr3:152348025-152348797 773 nt 0.3079
hsa_MBNL1_0009100 Intron-Exon-Intron chr3:152066076-152133246 chr3:152348287-152415457 85 nt 0.3882
hsa_chr3_0289800 Intergenic-Intergenic chr3:152066795-152067096 chr3:152349006-152349307 302 nt 0.3907
hsa_MBNL1_0009200 Intron-Intron chr3:152068345-152068498 chr3:152350556-152350709 154 nt 0.3961
hsa_MBNL1_0009300 Intron-Intron chr3:152076737-152077204 chr3:152358948-152359415 468 nt 0.2885
hsa_MBNL1_0009400 Intron-Intron chr3:152077414-152077965 chr3:152359625-152360176 552 nt 0.3678
hsa_MBNL1_0009500 Intron-Exon-Intron chr3:152078984-152132900 chr3:152361195-152415111 250 nt 0.3760
Showing 101 to 110 of 186 entries
Forensic Context

A study in mice and Drosophila demonstrated that the circMBNL1 regulates the production of its linear mRNA counterpart in cis through competition with canonical splicing [Patop et al. DOI:10.15252/embj.2018100836]. A separate review confirmed its role as a splicing competitor that adversely affects canonical pre-mRNA splicing [Misir et al. DOI:10.1038/s41418-022-00948-7]. Research in mammalian neural tissue indicates that the circMBNL1 is synaptically-enriched and abundant in the dendritic arbor, suggesting a role in synaptic function [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].