Basic Information

Symbol
circMBNL1
RNA Class
circRNA
Alias
Muscleblind Like Splicing Regulator 1 EXP KIAA0428 MBNL Triplet-Expansion RNA-Binding Protein Muscleblind-Like Protein 1 EXP42 EXP40 EXP35 Muscleblind-Like Splicing Regulator 1 Muscleblind (Drosophila)-Like Muscleblind-Like (Drosophila) Muscleblind-Like
Location (GRCh37)
3:151961621-152183569 UCSC Genome Browser
Location (GRCh38)
3:152243832-152465780
UCSC Genome Browser Search in Marker Scope
Host gene
MBNL1
Host category
mRNA
Forensic tag(s)
Other applications
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_MBNL1_0009600 Intron-Intron chr3:152079171-152079553 chr3:152361382-152361764 383 nt 0.3681
hsa_MBNL1_0009700 Intron-Intron chr3:152082871-152084449 chr3:152365082-152366660 1579 nt 0.3179
hsa_chr3_0289900 Intergenic-Intergenic chr3:152083425-152083714 chr3:152365636-152365925 290 nt 0.3000
hsa_chr3_0290000 Intergenic-Intergenic chr3:152083666-152084119 chr3:152365877-152366330 454 nt 0.3260
hsa_chr3_0290100 Intergenic-Intergenic chr3:152084257-152084793 chr3:152366468-152367004 537 nt 0.2775
hsa_MBNL1_0009800 Intron-Intron chr3:152090376-152090704 chr3:152372587-152372915 329 nt 0.5805
hsa_chr3_0290200 Intergenic-Intergenic chr3:152095228-152096214 chr3:152377439-152378425 987 nt 0.3455
hsa_chr3_0290300 Intergenic-Intergenic chr3:152097808-152098297 chr3:152380019-152380508 490 nt 0.3469
hsa_MBNL1_0009900 Intron-Intron chr3:152097876-152098033 chr3:152380087-152380244 158 nt 0.3354
hsa_MBNL1_0010000 Intron-Exon-Intron chr3:152100706-152150709 chr3:152382917-152432920 250 nt 0.3920
Showing 111 to 120 of 186 entries
Forensic Context

A study in mice and Drosophila demonstrated that the circMBNL1 regulates the production of its linear mRNA counterpart in cis through competition with canonical splicing [Patop et al. DOI:10.15252/embj.2018100836]. A separate review confirmed its role as a splicing competitor that adversely affects canonical pre-mRNA splicing [Misir et al. DOI:10.1038/s41418-022-00948-7]. Research in mammalian neural tissue indicates that the circMBNL1 is synaptically-enriched and abundant in the dendritic arbor, suggesting a role in synaptic function [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].