Basic Information

Symbol
circMBNL1
RNA Class
circRNA
Alias
Muscleblind Like Splicing Regulator 1 EXP KIAA0428 MBNL Triplet-Expansion RNA-Binding Protein Muscleblind-Like Protein 1 EXP42 EXP40 EXP35 Muscleblind-Like Splicing Regulator 1 Muscleblind (Drosophila)-Like Muscleblind-Like (Drosophila) Muscleblind-Like
Location (GRCh37)
3:151961621-152183569 UCSC Genome Browser
Location (GRCh38)
3:152243832-152465780
UCSC Genome Browser Search in Marker Scope
Host gene
MBNL1
Host category
mRNA
Forensic tag(s)
Other applications
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_chr3_0290400 Intergenic-Intergenic chr3:152101036-152101267 chr3:152383247-152383478 232 nt 0.3836
hsa_MBNL1_0010100 Intron-Intron chr3:152101481-152101619 chr3:152383692-152383830 139 nt 0.3381
hsa_MBNL1_0010200 Intron-Intron chr3:152104746-152104902 chr3:152386957-152387113 157 nt 0.3822
hsa_MBNL1_0010300 Intron-Intron chr3:152104746-152104955 chr3:152386957-152387166 210 nt 0.3476
hsa_MBNL1_0010400 Intron-Exon-Intron chr3:152105443-152134003 chr3:152387654-152416214 266 nt 0.4474
hsa_MBNL1_0010500 Intron-Intron chr3:152105757-152106737 chr3:152387968-152388948 981 nt 0.3925
hsa_MBNL1_0010600 Intron-Intron chr3:152106218-152106557 chr3:152388429-152388768 340 nt 0.4118
hsa_MBNL1_0010700 Intron-Intron chr3:152106414-152106557 chr3:152388625-152388768 144 nt 0.4097
hsa_chr3_0290500 Intergenic-Intergenic chr3:152108345-152108692 chr3:152390556-152390903 348 nt 0.4224
hsa_chr3_0290600 Intergenic-Intergenic chr3:152109212-152109713 chr3:152391423-152391924 502 nt 0.3865
Showing 121 to 130 of 186 entries
Forensic Context

A study in mice and Drosophila demonstrated that the circMBNL1 regulates the production of its linear mRNA counterpart in cis through competition with canonical splicing [Patop et al. DOI:10.15252/embj.2018100836]. A separate review confirmed its role as a splicing competitor that adversely affects canonical pre-mRNA splicing [Misir et al. DOI:10.1038/s41418-022-00948-7]. Research in mammalian neural tissue indicates that the circMBNL1 is synaptically-enriched and abundant in the dendritic arbor, suggesting a role in synaptic function [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].