Basic Information

Symbol
circMBNL1
RNA Class
circRNA
Alias
Muscleblind Like Splicing Regulator 1 EXP KIAA0428 MBNL Triplet-Expansion RNA-Binding Protein Muscleblind-Like Protein 1 EXP42 EXP40 EXP35 Muscleblind-Like Splicing Regulator 1 Muscleblind (Drosophila)-Like Muscleblind-Like (Drosophila) Muscleblind-Like
Location (GRCh37)
3:151961621-152183569 UCSC Genome Browser
Location (GRCh38)
3:152243832-152465780
UCSC Genome Browser Search in Marker Scope
Host gene
MBNL1
Host category
mRNA
Forensic tag(s)
Other applications
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_chr3_0290700 Intergenic-Intergenic chr3:152109253-152109489 chr3:152391464-152391700 237 nt 0.3882
hsa_MBNL1_0010800 Intron-Exon-Intron chr3:152110702-152132900 chr3:152392913-152415111 250 nt 0.3480
hsa_MBNL1_0010900 Intron-Exon-Intron chr3:152110813-152132900 chr3:152393024-152415111 171 nt 0.4912
hsa_MBNL1_0011000 Intron-Intron chr3:152110866-152111152 chr3:152393077-152393363 287 nt 0.4286
hsa_MBNL1_0011100 Intron-Exon-Intron chr3:152113651-152174150 chr3:152395862-152456361 1335 nt 0.5086
hsa_MBNL1_0011200 Intron-Intron chr3:152118837-152119065 chr3:152401048-152401276 229 nt 0.3406
hsa_MBNL1_0011300 Intron-Intron chr3:152120819-152121374 chr3:152403030-152403585 556 nt 0.3543
hsa_MBNL1_0011400 Intron-Intron chr3:152123376-152123913 chr3:152405587-152406124 538 nt 0.3420
hsa_MBNL1_0011500 Intron-Exon-Intron chr3:152129616-152165562 chr3:152411827-152447773 48 nt 0.2917
hsa_chr3_0290800 Intergenic-Intergenic chr3:152129952-152130269 chr3:152412163-152412480 318 nt 0.3491
Showing 131 to 140 of 186 entries
Forensic Context

A study in mice and Drosophila demonstrated that the circMBNL1 regulates the production of its linear mRNA counterpart in cis through competition with canonical splicing [Patop et al. DOI:10.15252/embj.2018100836]. A separate review confirmed its role as a splicing competitor that adversely affects canonical pre-mRNA splicing [Misir et al. DOI:10.1038/s41418-022-00948-7]. Research in mammalian neural tissue indicates that the circMBNL1 is synaptically-enriched and abundant in the dendritic arbor, suggesting a role in synaptic function [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].