Basic Information

Symbol
circMBNL1
RNA Class
circRNA
Alias
Muscleblind Like Splicing Regulator 1 EXP KIAA0428 MBNL Triplet-Expansion RNA-Binding Protein Muscleblind-Like Protein 1 EXP42 EXP40 EXP35 Muscleblind-Like Splicing Regulator 1 Muscleblind (Drosophila)-Like Muscleblind-Like (Drosophila) Muscleblind-Like
Location (GRCh37)
3:151961621-152183569 UCSC Genome Browser
Location (GRCh38)
3:152243832-152465780
UCSC Genome Browser Search in Marker Scope
Host gene
MBNL1
Host category
mRNA
Forensic tag(s)
Other applications
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_MBNL1_0012100 Exon-Exon chr3:152132730-152132900 chr3:152414941-152415111 171 nt 0.4912
hsa_MBNL1_0011700 Intron-Exon-Intron chr3:152132730-152138424 chr3:152414941-152420635 250 nt 0.3360
hsa_MBNL1_0012200 Intron-Exon-Intron chr3:152132730-152147386 chr3:152414941-152429597 171 nt 0.4912
hsa_MBNL1_0012300 Intron-Exon-Intron chr3:152132730-152155235 chr3:152414941-152437446 287 nt 0.4704
hsa_MBNL1_0012400 Exon-Exon chr3:152132730-152163328 chr3:152414941-152445539 732 nt 0.4754
hsa_MBNL1_0012600 Exon-Exon chr3:152132730-152173366 chr3:152414941-152455577 877 nt 0.5040
hsa_MBNL1_0012700 Exon-Exon chr3:152132730-152174150 chr3:152414941-152456361 137 nt 0.5693
hsa_MBNL1_0012800 Exon-Exon chr3:152132730-152177134 chr3:152414941-152459345 450 nt 0.4889
hsa_MBNL1_0012900 Exon-Exon chr3:152132730-152180223 chr3:152414941-152462434 225 nt 0.4444
hsa_MBNL1_0013000 Exon-Exon chr3:152132730-152182912 chr3:152414941-152465123 117 nt 0.4274
Showing 141 to 150 of 186 entries
Forensic Context

A study in mice and Drosophila demonstrated that the circMBNL1 regulates the production of its linear mRNA counterpart in cis through competition with canonical splicing [Patop et al. DOI:10.15252/embj.2018100836]. A separate review confirmed its role as a splicing competitor that adversely affects canonical pre-mRNA splicing [Misir et al. DOI:10.1038/s41418-022-00948-7]. Research in mammalian neural tissue indicates that the circMBNL1 is synaptically-enriched and abundant in the dendritic arbor, suggesting a role in synaptic function [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].