Basic Information

Symbol
circMBNL1
RNA Class
circRNA
Alias
Muscleblind Like Splicing Regulator 1 EXP KIAA0428 MBNL Triplet-Expansion RNA-Binding Protein Muscleblind-Like Protein 1 EXP42 EXP40 EXP35 Muscleblind-Like Splicing Regulator 1 Muscleblind (Drosophila)-Like Muscleblind-Like (Drosophila) Muscleblind-Like
Location (GRCh37)
3:151961621-152183569 UCSC Genome Browser
Location (GRCh38)
3:152243832-152465780
UCSC Genome Browser Search in Marker Scope
Host gene
MBNL1
Host category
mRNA
Forensic tag(s)
Other applications
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_MBNL1_0013100 Exon-Exon chr3:152132790-152150709 chr3:152415001-152432920 315 nt 0.5143
hsa_MBNL1_0013200 Exon-Exon chr3:152132790-152164546 chr3:152415001-152446757 117 nt 0.4957
hsa_MBNL1_0013300 Intron-Intron chr3:152133483-152133703 chr3:152415694-152415914 221 nt 0.3122
hsa_chr3_0290900 Intergenic-Intergenic chr3:152135258-152136484 chr3:152417469-152418695 1227 nt 0.4262
hsa_MBNL1_0013400 Intron-Intron chr3:152135476-152135813 chr3:152417687-152418024 338 nt 0.4290
hsa_MBNL1_0013500 Intron-Intron chr3:152141078-152141290 chr3:152423289-152423501 213 nt 0.3944
hsa_MBNL1_0013600 Intron-Exon-Intron chr3:152149476-152165562 chr3:152431687-152447773 148 nt 0.3378
hsa_MBNL1_0013800 Exon-Exon chr3:152150506-152150709 chr3:152432717-152432920 204 nt 0.5294
hsa_MBNL1_0013700 Intron-Exon-Intron chr3:152150506-152155235 chr3:152432717-152437446 250 nt 0.3440
hsa_MBNL1_0013900 Exon-Exon chr3:152150506-152163328 chr3:152432717-152445539 462 nt 0.5152
Showing 151 to 160 of 186 entries
Forensic Context

A study in mice and Drosophila demonstrated that the circMBNL1 regulates the production of its linear mRNA counterpart in cis through competition with canonical splicing [Patop et al. DOI:10.15252/embj.2018100836]. A separate review confirmed its role as a splicing competitor that adversely affects canonical pre-mRNA splicing [Misir et al. DOI:10.1038/s41418-022-00948-7]. Research in mammalian neural tissue indicates that the circMBNL1 is synaptically-enriched and abundant in the dendritic arbor, suggesting a role in synaptic function [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].