Basic Information

Symbol
circMBNL1
RNA Class
circRNA
Alias
Muscleblind Like Splicing Regulator 1 EXP KIAA0428 MBNL Triplet-Expansion RNA-Binding Protein Muscleblind-Like Protein 1 EXP42 EXP40 EXP35 Muscleblind-Like Splicing Regulator 1 Muscleblind (Drosophila)-Like Muscleblind-Like (Drosophila) Muscleblind-Like
Location (GRCh37)
3:151961621-152183569 UCSC Genome Browser
Location (GRCh38)
3:152243832-152465780
UCSC Genome Browser Search in Marker Scope
Host gene
MBNL1
Host category
mRNA
Forensic tag(s)
Other applications
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_MBNL1_0014000 Exon-Exon chr3:152150506-152165562 chr3:152432717-152447773 412 nt 0.4927
hsa_MBNL1_0014100 Exon-Exon chr3:152150506-152177134 chr3:152432717-152459345 75 nt 0.3733
hsa_chr3_0291000 Intergenic-Intergenic chr3:152150972-152151182 chr3:152433183-152433393 211 nt 0.3175
hsa_MBNL1_0014200 Intron-Exon-Intron chr3:152155153-152163328 chr3:152437364-152445539 341 nt 0.4604
hsa_chr3_0291100 Intergenic-Intergenic chr3:152158958-152159193 chr3:152441169-152441404 236 nt 0.2797
hsa_MBNL1_0014300 Exon-Exon chr3:152163071-152163328 chr3:152445282-152445539 258 nt 0.5039
hsa_MBNL1_0014500 Exon-Exon chr3:152163071-152173366 chr3:152445282-152455577 90 nt 0.5222
hsa_MBNL1_0014600 Exon-Exon chr3:152163071-152177134 chr3:152445282-152459345 265 nt 0.4453
hsa_MBNL1_0014700 Exon-Exon chr3:152163145-152165562 chr3:152445356-152447773 392 nt 0.5026
hsa_chr3_0291200 Intergenic-Intergenic chr3:152163160-152165514 chr3:152445371-152447725 329 nt 0.5106
Showing 161 to 170 of 186 entries
Forensic Context

A study in mice and Drosophila demonstrated that the circMBNL1 regulates the production of its linear mRNA counterpart in cis through competition with canonical splicing [Patop et al. DOI:10.15252/embj.2018100836]. A separate review confirmed its role as a splicing competitor that adversely affects canonical pre-mRNA splicing [Misir et al. DOI:10.1038/s41418-022-00948-7]. Research in mammalian neural tissue indicates that the circMBNL1 is synaptically-enriched and abundant in the dendritic arbor, suggesting a role in synaptic function [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].